2005 Fiscal Year Final Research Report Summary
Exploratory study of genetic phenotypes in schizophrenia with brain morphometry and ^1H-MRS
| Project/Area Number |
16390322
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
TAKEI Norigoshi Hamamatsu U Sch Med, Psychiatry, Associate Professor, 医学部, 助教授 (80206937)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAI Masayoshi Hamamatsu U Sch Med, Psychiatry, Assistant, 医学部, 助手 (30283352)
MORI Norio Hamamatsu U Sch Med, Psychiatry, Professor, 医学部, 教授 (00174376)
ISODA Haruo Hamamatsu U Sch Med, Radiology, Associate Professor, 医学部, 助教授 (40223060)
SAKAHARA Harumi Hamamatsu U Sch Med, Radiology, Professor, 医学部, 教授 (10187031)
NAKAMURA Kazuhiko Hamamatsu U Sch Med, Psychiatry, Lecturer, 医学部附属病院, 講師 (80263911)
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| Project Period (FY) |
2004 – 2005
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| Keywords | Schizophrenia / MRS / High risk / Phenotype |
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| Research Abstract |
Schizophrenia is considered to be a neurobiological disorder and have a genetic liability. The examination of relatives of subjects with schizophrenia is one approach to detect the fundamental neurobiological characteristics more directly linked to gene expression.
In this study, we assessed neurochemical indices, using ^1H-MRS, in the left dorsolateral prefrontal, anterior cingulate, left hippocampus, and left striatum in the offspring (n=6) of parents with schizophrenia (‘high risk' (HR) individuals) and in healthy controls (HC) (n=4). We also evaluated cognitive performance in each individual of the subjects with Wechsler Adult Intelligence Scale revised (WAIS-R), Wechsler Memory Scales revised (WMS-R) and the Cambridge Automated Neuropsychological Test Battery (CANTAB).
Although HR subjects had relatively lower NAA in all of the 4 regions studied compared with HC subjects, these differences did not reach the conventional level of statistical significance. In the left DLPFC, the Cho level was significantly lower in the HR group (mean±s.d.;3.0±0.42) than in the HC group (4.1±0.32) (p=0.003). As for the neuropsychological tests, HR subjects had impaired performance, at a trend level, on spatial working memory task and Stroop test, compared to HC subjects.
Our finding of comparatively low Cho level in the left DLPFC in the HR subjects may suggest that membrane "turnover" is suppressed in HR subjects in some areas of the brain, especially in the left DLPFC. However, this is a preliminary study. To confirm the findings, we will recruit more subjects and continue to obtain data with which to explore the relationships between brain metabolite alterations related to genetic predisposition to schizophrenia and cognitive functions.
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Research Products
(54 results)
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[Journal Article] Brain Serotonin Transporter Density and Aggression in Abstinent Methamphetamine Abusers.2006
Author(s)
Sekine Y., Ouchi Y., Takei N., Yoshikawa E., Nakamura K., Futatsubashi M., Okada H., Minabe Y., Suzuki K., Iwata Y., Tsuchiya K.J., Tsukada H., Iyo M., Mori N.
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Journal Title
Arch.Gen.Psychiar. 63(1)
Pages: 90-100
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Evidence that variation in the peripheral benzodiazepine receptor (PBR) gene influences susceptibility to panic disorder.2006
Author(s)
Nakamura K., Yamada K., Iwayama Y., Toyota T., Furukawa A., Takimoto T., Terayama H., Iwahashi K., Takei N., Minabe Y., Sekine Y., Suzuki K., Iwata Y., Pillai A., Nakamoto Y., Ikeda K., Yoshii M., Fukunishi I., Yoshikawa T., Mori N.
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Journal Title
Am J Med Genet B Neuropsychiatr Genet. 141B(3)
Pages: 222-226
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Association between schizophrenia with ocular misalignment and polyalanine length variation in PMX2B.2004
Author(s)
Toyota T., Yoshitsugu K., Ebihara M., Yamada K., Ohba H., Fukasawa M., Minabe Y., Nakamura K., Sekine Y., Takei N., Suzuki K., Itokawa M., Meerabux J.M., Iwayama-Shigeno Y., Tomaru Y., Shimizu H., Hattori E., Mori N., Yoshikawa T
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Journal Title
Hum Mol Genet. 13(5)
Pages: 551-561
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Association between the glutathione S-transferase M1 gene deletion and female methamphetamine abusers.2004
Author(s)
Koizumi H., Hashimoto K., Kumakiri C., Shimizu E., Sekine Y., Ozaki N., Inada T., Harano M., Komiyama T., Yamada M., Sora I., Ujike H., Takei N., Iyo M.
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Journal Title
Am.J.Med.Genet. 126B(1)
Pages: 43-45
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Metabolite Alterations in Basal Ganglia Associated with Psychiatric Symptoms of Abstinent Toluene Users : A Proton MRS Study.2004
Author(s)
Takebayashi K., Sekine Y., Takei N., Minabe Y., Isoda H., Takeda H., Nishimura K., Nakamura K., Suzuki K., Iwata Y., Sakahara H., Mori N.
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Journal Title
Neuropsychopharmacol. 29(5)
Pages: 1019-1026
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Obstetric adversity and age at the first presentation in schizophrenia : evidence of a casual relationship.2004
Author(s)
Kelly B.D., Feeney L., Browne R., Byrne M., Mulryyan N., Scully A., Morris M., Kinesella A., Takei N., McNeil T., Walsh D., Larkin C., O'Callaghan E.
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Journal Title
Am.J.Psychiatr. 161(5)
Pages: 920-922
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Association analysis of FEZ1 variants with schizophrenia in Japanese cohorts.2004
Author(s)
Yamada K., Nakamura K., Minabe Y., Iwayama-Shigeno Y., Takao H., Toyota T., Hattori E., Takei N., Sekine Y., Suzuki K., Iwata Y., Miyoshi K., Honda A., Baba K., Katayama T., Tohyama M., Mori N., Yoshikawa T
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Journal Title
Biol.Psychiatr. 56(9)
Pages: 683-690
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] An association study between COMT gene polymorphism and methamphetamine psychotic disorder.
Author(s)
Suzuki A., Nakamura K., Sekine Y., Minabe Y., Takei N., Suzuki K., Iwata Y., Kawai M., Takebayashi K., Iyo M., Ozaki N., Inada T., Iwata N., Harano M., Komiyama T., Yamada M., Sora I., Ujike H., Mori N
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Journal Title
Psychiat.Genet. (In press)
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Novel scale including strabismus and 'cuspidal ear' for distinguishing schizophrenia patients from controls using minor physical anomalies.
Author(s)
Yoshitsugu K., Yamada K., Toyota T., Aoki-Suzuki M., Minabe Y., Nakamura K., Sekine Y., Suzuki K., Takei N., Itokawa M., Mori M., Yoshikawa T.
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Journal Title
Psychiatr.Res. (In press)
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations.
Author(s)
Nakamura K., Chen C., Sekine Y., Iwata Y., Pillai A., Loh E., Takei N., Suzuki A., Kawai M., Takebayashi K., Suzuki K., Minabe Y., Tsuchiya K., Yamada K., Iyo M., Ozaki N., Inada T., Iwata N., Harano M., Komiyama T., Yamada M., Sora I., Ujike H., Ball D., Yoshikawa T., Lin S., Mori N.
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Description
「研究成果報告書概要(欧文)」より
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