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2006 Fiscal Year Final Research Report Summary

Metal contamination and chromosome instability in a population around Chernobyl Nuclear Power Plant

Research Project

Project/Area Number 16406020
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Hygiene
Research InstitutionNagasaki University

Principal Investigator

SAITO Hiroshi  Nagasaki University, President, 学長 (80004901)

Co-Investigator(Kenkyū-buntansha) SHIBATA Yoshisada  Nagasaki University Graduate School of Biomedical Sciences, Professor, 大学院医歯薬学総合研究科, 教授 (40010954)
TAKAMURA Noboru  Nagasaki University Graduate School of Biomedical Sciences, Associate Professor, 大学院医歯薬学総合研究科, 助教授 (30295068)
WATANABE Takao  Miyagi University of Education, Professor, 教育学部, 教授 (20004608)
NAKANO Atsuhiro  National Institute for Minamata Disease, Dean, 基礎研究部, 部長 (20041329)
Project Period (FY) 2004 – 2006
KeywordsChernobyl / Heavy metal contamination / Iodine / Thyroid Cancer / Porphyrin
Research Abstract

Although it is well know that childhood thyroid cancer has been dramatically increased after the accident at the Chernobyl Nuclear Power Plant on 1983, little is known on its mechanism. On the other hand, it has been recently reported that heavy metals, such as leads was released to the contaminated areas for the purpose of the decontamination, and the contamination map of these metals has been prepared. However, there is no report on the health effects in population residing in this area. Recently, it has been reported the chromosomal instability by the exposure of heavy metals such as cadmium and nickel in vitro, which suggests that metal exposure might be a cause of chromosomal instability, same as radiation exposure. In this point of view, we aimed to evaluate the current situation of heavy metal contamination in this area, and clarify the chromosomal changes, in cooperation with the Institute of Radiation Medicine of Ukraine (Kiev).
Based on the previous results, we evaluated the contamination levels of heavy metals using hairs, but no significant correlation was observed with soil contamination levels. On the other hand, a certain trace element was elevated, which suggests that further evaluation is needed.
On July 2006, we conducted the international symposium at Nagasaki University, to review our research activity during three years. Simultaneously, we invited specialist from China and the Republic of Belarus, in order to expand our research network in this area.

  • Research Products

    (26 results)

All 2007 2006 Other

All Journal Article (26 results)

  • [Journal Article] Cadmium-induced renal dysfunction and mortality in two cohorts : Disappearance of the association in a generation born later.2007

    • Author(s)
      Arisawa K, Saito H他
    • Journal Title

      Toxicol Lett 169・3

      Pages: 214-221

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The possibility of a valuable resource of circulating DNA for single nucleotide polymorphism genotyping : the application of a rapid and simple polymerase chain reaction.2007

    • Author(s)
      Mori S, Takamura N他
    • Journal Title

      Lab Hematol 13・1

      Pages: 1-5

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cadmium-induced renal dysfunction and mortality in two cohorts : Disappearance of the association in a generation born later.2007

    • Author(s)
      Arisawa K, Saito H et al.
    • Journal Title

      Toxicol Lett. 169 (3)

      Pages: 214-21

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The possibility of a valuable resource of circulating DNA for single nucleotide polymorphism genotyping : the application of a rapid and simple polymerase chain reaction.2007

    • Author(s)
      Mori S, Takamura N et al.
    • Journal Title

      Lab Hematol 13 (1)

      Pages: 1-5

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Evaluation of cardiovascular risk factors and related clinical markers in healthy young Japanese adults.2007

    • Author(s)
      Yagura C, Takamura N et al.
    • Journal Title

      Clin Chem Lab Med 45 (2)

      Pages: 220-5

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Folic acid deficiency : main etiological factor of megaloblastic anemia in Kazakhstan?2006

    • Author(s)
      Akilzhanova A, Takamura N他
    • Journal Title

      Am J Hematol 81・6

      Pages: 471

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Kazakhstan : a folate-deficient area?2006

    • Author(s)
      Akilzhanova A, Takamura N他
    • Journal Title

      Eur J Clin Nutr 60・9

      Pages: 1141-1143

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Effect of B vitamins and genetics on success of in-vitro fertilisation.2006

    • Author(s)
      Akilzhanova A, Takamura N他
    • Journal Title

      Lancet 368・9531

      Pages: 200-201

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Self-perceived oral health status and influencing factors of the elderly residents of a peri-urban area of La Paz, Bolivia.2006

    • Author(s)
      Ugarte J, Takamura N他
    • Journal Title

      Int Dent J 57・1

      Pages: 19-26

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Evaluation of cardiovascular risk factors and related clinical markers in healthy young Japanese adults.2006

    • Author(s)
      Yagura C, Takamura N他
    • Journal Title

      Clin Chem Lab Med 45

      Pages: 200-201

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Evaluation of clinical markers of atherosclerosis in young and elderly Japanese adults.2006

    • Author(s)
      Hara T, Takamura N他
    • Journal Title

      Clin Chem Lab Med 44・8

      Pages: 824-829

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Determinants of self-rated health among community-dwelling women aged 40 years and over in Japan.2006

    • Author(s)
      Kanagae M, Takamura N他
    • Journal Title

      Tohoku J Exp Med 210・1

      Pages: 11-19

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Folic acid deficiency : main etiological factor of megaloblastic anemia in Kazakhstan?2006

    • Author(s)
      Akilzhanova A, Takamura N et al.
    • Journal Title

      Am J Hematol 81 (6)

      Pages: 471

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Kazakhstan : a folate-deficient area?2006

    • Author(s)
      Akilzhanova A, Takamura N et al.
    • Journal Title

      Eur J Clin Nutr 60 (9)

      Pages: 1141-3

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Effect of B vitamins and genetics on success of in-vitro fertilisation.2006

    • Author(s)
      Akilzhanova A, Takamura N et al.
    • Journal Title

      Lancet 368 (9531)

      Pages: 200-1

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Self-perceived oral health status and influencing factors of the elderly residents of a peri-urban area of La Paz, Bolivia.2006

    • Author(s)
      Ugarte J, Takamura N et al.
    • Journal Title

      Int Dent J 57(1)

      Pages: 19-26

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Obesity and cardiovascular risk factors among men and women aged 40 years and older in a rural area of Japan.2006

    • Author(s)
      Aoyagi K, Takamura N et al.
    • Journal Title

      J Physiol Anthropol 25 (6)

      Pages: 371-5

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Evaluation of clinical markers of atherosclerosis in young and elderly Japanese adults.2006

    • Author(s)
      Hara T, Takamura N et al.
    • Journal Title

      Clin Chem Lab Med 44 (8)

      Pages: 824-9

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Determinants of self-rated health among community-dwelling women aged 40 years and over in Japan.2006

    • Author(s)
      Kanagae M, Takamura N et al.
    • Journal Title

      Tohoku J Exp Med 210 (1)

      Pages: 11-9

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Ukraine Urinary Iodine Levels; 20 years after the Chernobyl accident.

    • Author(s)
      Takamura N他
    • Journal Title

      Endocr J (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] RET Oncogene Amplification in Thyroid Cancer : Correlations with Radiation-associated and High-grade Malignancy.

    • Author(s)
      Nakashima M, Takamura N他
    • Journal Title

      Human Pathol (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Evaluation of fat-free mass by whole-body counter in Japanese healthy young adults.

    • Author(s)
      Morita M, Takamura N他
    • Journal Title

      Radiat Prot Dosimetry (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Ukraine Urinary Iodine Levels; 20 years after the Chernobyl accident.

    • Author(s)
      Takamura N他
    • Journal Title

      Endocr J (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Ukraine Urinary Iodine Levels; 20 years after the Chernobyl accident.

    • Author(s)
      Takamura N, Saito H et al.
    • Journal Title

      Endocr J (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] RET Oncogene Amplification in Thyroid Cancer : Correlations with Radiation-associated and High-grade Malignancy.

    • Author(s)
      Nakashima M, Takamura N et al.
    • Journal Title

      Human Pathol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Evaluation of fat-free mass by whole-body counter in Japanese healthy young adults.

    • Author(s)
      Morita M, Takamura N et al.
    • Journal Title

      Radiat Prot Dosimetry (in press)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2008-05-27  

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