2005 Fiscal Year Final Research Report Summary
Functional scaffold with recombinant human basic fibroblast growth factor for artificial organs and biomaterials, with angiogenesis and tissue reconstruction ability
| Project/Area Number |
16500304
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
TOMIZAWA Yasuko Tokyo Women's Medical University, Dept of Cardiovascular Surgery, Instructor, 医学部, 助手 (00159047)
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| Project Period (FY) |
2004 – 2005
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| Keywords | angiogenesis / scaffold / reconstruction / collagen / artificial organ / biomaterial / cytokine / wound healing |
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| Research Abstract |
It is well known that collagen is a biocompatible material, however commercially available collagen hemostats are not equally made and cell affinity is different between the products.
For natural wound healing, the combination of cells, cytokines and scaffolds are the important factors to accelerate the healing. During angiogenesis in wound healing in a rabbit ear chamber model, angiogenesis was accelerated with cotton type atelo-collagen fiber, and recombinant human basic fibroblast growth factor (rhbFGF). We hypothesized that collagen fiber might absorb rhbFGF and worked as functional scaffold. This combination work in vivo, we could apply this into artificial organs and biomaterials to obtain angiogenesis and tissue reconstruction, as we plan.
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Research Products
(16 results)
