2005 Fiscal Year Final Research Report Summary
Electrophysiological heart simulator with sketchy three-dimensional modeling interface
| Project/Area Number |
16500311
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
NAKAZAWA Kazuo National Cardiovascular Center Research Institute, Laboratory of Development and Evaluation of Biomedical Instruments and Systems, Laboratory Chief, 研究機器管理室, 室長 (50198058)
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| Co-Investigator(Kenkyū-buntansha) |
IGARASHI Takeo The University of Tokyo, Graduate School of Information Science and Technology, Associate Professor, 大学院・理工学系研究科, 助教授 (80345123)
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| Project Period (FY) |
2004 – 2005
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| Keywords | interface / electrophysiology / arrhythmia / simulation / visualization / sketch |
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| Research Abstract |
In this study, we have developed several experimental systems aiming to apply the electrophysiological heart simulation to the future clinical use. These systems are mainly composed of three functions : the first is a modeling interface to process volume or surface model for awkward three-dimensional heart geometry, the second is an execution environment for computer simulation that selects the simulation method according to the purpose and executes it efficiently, and the third is effective visualization of the simulation results.
Although many limitations exist yet, we can process the three-dimensional heart geometry model and set the electrophysiological parameters of it comparatively easily using our modeling interface. Two kinds of mathematical equation models for the electrophysiological heart behavior are alternative for the execution of the simulation according to the purpose. When promptness and handiness are important, the simulation with a personal computer can be executed al
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most in real time by using the FHN equation model as a simple type. It is very effective when medical staff briefly explains the outline of arrhythmia to the patient on the bed side for example. On the other hand, when accuracy is more important, it is also possible to execute a large-scale calculation with the LR equation model which is one of the complicated ion channel models by using the super computer. It is suitable for detailed investigation of the mechanism of arrhythmia.
In addition, we tentatively operated a network system. In this system, first a user accesses a WWW Server at the Shiga University of Medical Science, and specifies the parameters of action potential, the generation site of the premature ventricular contraction, and etc. Then the specified parameters is transmitted to the National Cardiovascular Center, and the simulation is executed by a super-computer. The calculation results are visualized and transformed into image data by a visualization server at the National Cardiovascular Center. Finally these image data are sent back to the Shiga University of Medical Science and registered with the WWW Server. Consequently the user can inspect the simulation results as effective visualized data by using a Web browser.
It seems that the development of these systems is effective to demonstrate the feature of the simulation research because the repetition experiment that changes electrophysiological parameters of the heart model can be easily conducted. Less
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Research Products
(13 results)
