2007 Fiscal Year Final Research Report Summary
Non-diffusible molecules determining the cell position in morphogenesis of multi-cellular organisms
| Project/Area Number |
16570182
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Hyogo University |
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Principal Investigator |
HONDA Hisao Hyogo University, Faculty of Health Science, Professor (10289118)
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| Project Period (FY) |
2004 – 2007
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| Keywords | Non-diffusible molecules / Molecules determining cell position / cell models for tissues / Epithelium |
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| Research Abstract |
In morphogenesis of multi-cellular organisms, cell positioning in tissues is important. Although some diffusible molecules are well known to work in morphogenesis, non-diffusible molecules must be important in morphogenesis of cell aggregates, because cells in the aggregate interact with each other by direct cell-cell contact. (1) In the present research project, ephrins and their receptor molecules are noted as non-diffusible molecules. These molecules were suggested to work in a classic experimental system of regeneration of retino-tectal projection. (2) To investigate the non-diffusible molecules in morphogenesis, a cell model for tissues is necessary. We construct a 3D cell model consisting of polyhedra forming an epithelial shell. The epithelial shell is an envelope of monolayered cells with a cavity. (3) Furthermore, when cells of the epithelial shell produce force in a polarized direction, the epithelial shell was shown to perform a polarized morphogenesis. Therefore, I succeeded in construction of the 3D epithelial cell model, by which I can investigate function of non-diffusible molecules in morphogenesis, e.g., epithelial cell invagination.
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Research Products
(40 results)
