2005 Fiscal Year Final Research Report Summary
Evaluation of heart functions using dual radiopharmaceuticals and its application to heart diseases.
| Project/Area Number |
16590107
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Niigata University |
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Principal Investigator |
TAKAHASHI Toshihiro Niigata University, Institute of Medicine and Dentistry, Professor, 医歯学系, 教授 (70143039)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Ken-ichi Niigata University of Pharmacy and Applied Life Sciences, Department of Clinical Pharmacology, Professor, 臨床薬理学教室, 教授 (70175090)
NAITOH Makoto Niigata University, Institute of Medicine and Dentistry, Professor, 医歯学系, 教授 (30045786)
IZUMIKAWA Takuji Niigata University, Radioisotope Center, Associate Professor, アイソトープ総合センター, 助教授 (60282985)
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| Project Period (FY) |
2004 – 2005
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| Keywords | heart function / heart accumulating radiopharmaceutical / labeled fatty acid / myocardial fatty acid metabolism / labeled sugar / labeled agent for sympathetic nervous function / myocardial energy efficiency |
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| Research Abstract |
In this study, we propose the evaluational method of two kinds of heart functions using dual heart accumulating radiopharmaceuticals. The used radiopharmaceuticals were [I-125]9MPA for myocardial fatty acid metabolism, [I-125]MIBG for study of heart sympathetic nervous function and [C-14]2DG for sugar metabolism and the used animals were normal rat (standard heart) and CHF (chronic heart failure) rat, which is a rat model of dilated cardiomyopathy induced by autoimmune myocarditis. Using above-mentioned materials, we performed some animal studies about time (after injection)-heart uptake study, fatty acid metabolic study, autoradiography, etc. In result, in the CHF heart, both the fatty acid metabolic function and the heart sympathetic nervous function were damaged, but the sugar metabolic function was activated. These results have been suggested that the energy efficiency in the CHF heart changes from fatty acid use to sugar use. Further, it has been also shown that the heart size becomes larger with increasing the severity of heart damage (the relatively good correlation between heart weight (heart size) and 9MPA/MIBG heart uptake) and in the CHF heart, the storage metabolic route is mainly damaged by the fatty acid metabolic study.
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[Journal Article] Evaluation of cardiac function using dual radiopharmaceuticals. - Relationship between heart uptake and heart weight -2006
Author(s)
Sakuma K., Takahashi T., Watanabe K., Watanabe, Y., Yazawa Y., Chiba R., Kitagawa Y., Ma M., Suresh P., Juan W., Kamal F., Prakash P., Nagai Y., Sega T., Tazawa S.
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Journal Title
The Pharmaceutical Society of Japan, Annual Meeting (Abstract) Vol.2 No.126
Pages: 65
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Evaluation of cardiac function in rats with dilated cardiomyopathy using labeled fatty acids - Relationship between heart uptake and heart size -2005
Author(s)
Takahashi T., Yamaguchi S., Sakuma K., Watanabe K., Wahed M.I.I., Ma M., Narasimman G., Suresh P., Juan W., Kamal F., Shirai K., Soga M., Nagai Y., Sega T., Tazawa S.
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Journal Title
The Pharmaceutical Society of Japan, Annual Meeting (Abstract) Vol.2, No.125
Pages: 75
Description
「研究成果報告書概要(欧文)」より
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