2005 Fiscal Year Final Research Report Summary
Tissue distribution and application for diagnostic pathology of membrane aminopeptidases
| Project/Area Number |
16590274
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Nagoya University |
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Principal Investigator |
NAGASAKA Tetsuro Nagoya University, Graduate School of medicine, Associate Professor, 大学院・医学系研究科, 助教授 (40262894)
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| Co-Investigator(Kenkyū-buntansha) |
NOMURA Seiji Nagoya University, Graduate School of medicine, Associate Professor, 大学院・医学系研究科, 助教授 (20242860)
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| Project Period (FY) |
2004 – 2005
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| Keywords | Aminopeptidases / P-LAP / Pancreatic islet / GLUT4 / VEGF receptor / Angiotensin II receptor / Uterine sarcoma / Ovarian cancer |
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| Research Abstract |
In order to clarify the tissue distribution of membrane aminopeptidases and their roles for the tumor progression, immunohistchemical studies using antibodies for each aminopeptidases were done. Membrane aminopeptidases studied in this project were CD10, CD13, CD26, APA, P-LAP and A-LAP. New findings in this project were as follows ; P-LAP was locateded in human pancreatic islets and its distribution was closely associated with GLUT4 vesicles. A-LAP was located in human endometrial glands especially in the secretory vesicles like P-LAP. The distribution of A-LAP during menstral cycle is closely related with P-LAP. In the gynecological tumor, expression of P-LAP in endometrial carcinoma tissue is associated with poor outcome. Expression of VEGF and VEGF receptor in uterine sarcoma were associated with their prognosis. Expression of Angiotensin II type1 receptor were associated with tumor angiogenesis and prognosis in ovarian cancer.
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