2005 Fiscal Year Final Research Report Summary
The role of non-receptor tyrosine kinase Fyn in neurodegeneration of prion diseases
| Project/Area Number |
16590302
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Tohoku University |
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Principal Investigator |
MURAMOTO Tamaki Tohoku University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (40302096)
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| Co-Investigator(Kenkyū-buntansha) |
YAGI Takeshi Osaka University, Graduate School of Frontier Biosciences, Professor, 大学院・生命科学研究科, 教授 (10241241)
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| Project Period (FY) |
2004 – 2005
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| Keywords | tyrosine kinase / fyn / knock-out / prion disease / neurodegeneration |
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| Research Abstract |
In order to explore the role of non-receptor tyrosine kinase Fyn in neurodegeneration of prion diseases, experimental prion diseases in mice homo- and hemi-zygotic for fyn-knockout allele were analyzed and compared with that in wild type mice. The diseases had indistinguishable incubation periods and shared all typical findings including clinical manifestations, spongiform degeneration and accumulation of protease-resistant prion protein in the brain tissue irrespective of mouse genotype. The deficiency of this single Src family tyrosine kinase seems not to affect prion pathogenesis.
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