2005 Fiscal Year Final Research Report Summary
Research for health problem after adolescence of the patients with Down syndrome
| Project/Area Number |
16590516
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Tokyo Kasei University |
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Principal Investigator |
TAKANO Takako Tokyo Kasei University, 家政学部, 教授 (50236246)
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| Co-Investigator(Kenkyū-buntansha) |
HIGURASHI Makoto Tokyo Kasei University (00010223)
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| Project Period (FY) |
2004 – 2005
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| Keywords | Down syndrome / adolescence / menarche / seminal discharge |
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| Research Abstract |
We examined the patients with DS aged 10 years and older together with their siblings in 2004. Data were analyzed using questionnaires completed by their families (mainly mothers). The total 121 children with DS (62 females and 59 males) were compared with the total 121 siblings (66 females and 55 males). Mean age of DS was 20.3 ± 7.3 years and that of the siblings was 21.2 ± 8.5 years. Mean age of menarche and onset of mammary growth of female DS were not delayed. Though female mean age of growth of axillary and pubic hair was delayed, an interest in male and rebellious attitude to parents was shown almost at the same age as siblings'. As to male, the onset of adolescence was hardly delayed except for an interest in female. Most frequent complication in adulthood was obesity which has appeared in half of the patient, and next to it, sleep apnea, hyperuricema in male, thyroid disease in female was frequent. We have detected sperms in the sample of underclothes of 2 adults with DS by a microscope. Data of normal serum testosterone, slightly high LH and high FSH resembled those to azoospermia. Parents had better prepare for virtually normal onset of adolescence of children with both female and male DS and their adult life.
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Research Products
(9 results)
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[Book] 遺伝学事典2005
Author(s)
高野貴子他
Total Pages
325
Publisher
朝倉書店
Description
「研究成果報告書概要(和文)」より
