2005 Fiscal Year Final Research Report Summary
Relationship between serum growth factors or cytokines and prognosis of gastric cancer
| Project/Area Number |
16590521
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Aichi Medical University |
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Principal Investigator |
KIKUCHI Shogo Aichi Medical University, School of Medicine, Professor, 医学部, 教授 (40224901)
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| Co-Investigator(Kenkyū-buntansha) |
OBATA Yuki Aichi Medical University, School of Medicine, Research Associate, 医学部, 助手 (70340304)
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| Project Period (FY) |
2004 – 2005
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| Keywords | Interleukine-6 / Interleukine-8 / vascular endothelial growth factor / Prognosis of gastric cancer / Proportional hazard model / 5-year survival |
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| Research Abstract |
Of 571 gastric patients who underwent surgical operations with 5-year prognosis after the operations, 198 were the subjects of this study. Using the pre-operative sera of the subjects, IL (interleukine)-1β, IL-6, IL-8, TGF (transforming growth factor)-β, TNF (tumor necrosing factor)α, EGF (epidermal growth factor), Midkine, VEGF (vascular endothelial growth factor), VEGF receptor-1 and VEGF receptor-2 were measured. The endpoint was total death. Those who did not die during the following-up period, were defined as censored cases at the times of the last observations or 5 years after the operations. Using the serum growth factors or cytokines, the subjects were classified into 2 groups. Using Cox's proportional hazard models, risk of death was compared between the two groups adjusted for gender and age or for gender, age and progression stage. When adjusted for gander and age, high serum values of IL-6, IL-8 and VEGF were significantly related with poor prognosis, where hazard ratios were 2.27 (1.30, 3.96), 1.96 (1.11, 3.51) and 1.86 (1.00, 3.46), respectively. When adjusted for gender, age and progression stage, they were 1.67 (0.94, 2.99), 1.58 (0.88, 2.83) and 1.46 (0.76, 2.79), respectively.
IL-6 seems to be a prognostic factor relatively independent of progression stage. IL-8 seems to be one closely related with progression stage. VEGF may be a weaker prognostic factor. Further investigations with increased number of subjects seem to be required to clarify whether these factors are prognostic factors when effect of stage is excluded.
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