2006 Fiscal Year Final Research Report Summary
Research for usefulness of intestinal peptide, PYY_<3-36> for therapeutic agents of fatty liver and NASH
| Project/Area Number |
16590650
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kurume University |
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Principal Investigator |
UENO Takato Kurume University, Research Center for Innovative Cancer Therapy, Professor, 先端癌治療研究センター, 教授 (70176618)
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| Co-Investigator(Kenkyū-buntansha) |
TORIYAMA Takuji Kurume University, Second Department of Internal Medicine, Associate Professor, 医学部, 助教授 (60197986)
KOGA Hironori Kurume University, Second Department of Internal Medicine, Assistant Professor, 医学部, 講師 (90268855)
HASHIMOTO Osamu Kurume University, Second Department of Internal Medicine, Assistant, 医学部, 助手 (50289427)
川口 巧 久留米大学, 医学部, 助手 (00320177)
NAKAMURA Toru Kurume University, Second Department of Internal Medicine, Assistant, 医学部, 助手 (30341332)
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| Project Period (FY) |
2004 – 2006
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| Keywords | Fatty liver / NASH / PYY_<3-36> / Oxidative stress |
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| Research Abstract |
We examined the therapeutic effects of PYY_<3-36> on model animals showing obesity and fatty liver. Firstly, we studies using Zucker obesity model rats, and observed the effects of PYY_<3-36> in these rats. That is, 0-5μg/100g PYY per day was injected intraperitonialy for 30 days, and measured body weight point by point during observation term. In results, the increase of body weight of rats in the group treated with 5μg/100g PYY was significantly suppressed compared with that in the control group without treatment with PYY. However, nonalcoholic fatty liver diseases (NAFLD) containing nonalcoholic steatohepatitis (NASH) were not observed in liver tissues of these model rats. Next, we added the high calorie diet to the Zucker model rats for 1 month, and the characteristic findings of NASH such as intralobular inflammation, ballooning hepatocytes and Mallory's bodies were observed in the liver specimens. On the other hands, the histological findings of NASH were hardly observed in livers of the PYY-treated groups. However, the improvement of body weight was not recognized with PYY-treatment in this model rats, and we gave up a clinical trial, which treats with PYY in the patients with NAFLD and obesity.
Just at that moment, we reported that transgenic (Tg) mice which over express nSREBP-1c (nuclear sterol regulatory element-binding protein 1c) in fat tissues cause NASH. We examined the effects of green tea (-)-epigallocatechin-3-gallate (EGCG) in this nSREBP-1 Tg NASH model mice. That is, Water containing 0.05-0.1% EGCG was orally administrated for 3 months. In results, the increases of body weight and liver weight, and the progression of NASH were significantly suppressed with treatment of EGCG. Presently, we are studying whether the improvement of lipids, oxidative stress, insulin resistance and inflammation in the liver tissues are brought with EGCG treatment in the model mice.
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Research Products
(26 results)
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[Journal Article] High expression of insulin-like growth factor binding protein-3 is correlated with lower portal invasion and better prognosis in human hepatocellular carcinoma2006
Author(s)
Shinichi Aishima, Yuji Basaki, Yoshinao Oda, Yousuke Kuroda, Yunosuke Nishihara, Kenichi Taguchi, Akinobu Taketomi, Yoshihiko Maehara, Fumihito Hosoi, Yuichiro Maruyama, Abbas Fotovati, Shinji Oie, Mayumi Ono, Takato Ueno, Michio Sata, Hirohisa Yano, Masamichi Kojiro, Michihiko Kuwano, Masuzumi Tsuneyoshi
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Journal Title
Cancer sci 97
Pages: 1182-1190
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 32004
Author(s)
Takumi Kawaguchi, Takafumi Yoshida, Masaru Harada, Takao Hisamoto, Yumiko Nagao, Tatsuya Ide, Eitaro Taniguchi, Hiroto Kumemura, Shinichiro Harada, Michiko Maeyama, Shinji Baba, Hironori Koga, Ryukichi Kumashiro, Takato Ueno, Hisanobu Ogata, Akihiko Yoshi
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Journal Title
Am J Pathol 165
Pages: 1499-1508
Description
「研究成果報告書概要(欧文)」より
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