2005 Fiscal Year Final Research Report Summary
Novel anti-atherosclerotic and anti-thrombotic action of plasma heparin cofactor II
| Project/Area Number |
16590692
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
AZUMA Hiroyuki The University of Tokushima, Institute of Health Biosciences, Graduate School, Associate Professor, 大学院・ヘルスバイオサイエンス研究部, 助教授 (10241275)
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| Co-Investigator(Kenkyū-buntansha) |
MITSUI Takao The University of Tokushima, University Medical and Dental Hospital, Lecturer, 医学部・歯学部附属病院, 講師 (80294726)
AKAIKE Masashi The University of Tokushima, University Medical and Dental Hospital, Assistant, 医学部・歯学部附属病院, 助手 (90271080)
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| Project Period (FY) |
2004 – 2005
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| Keywords | thrombin / heparin cofactor II / atherosclerosis / coronary intervention / knockout mice / vascular remodeling / vascular smooth muscle cell / thrombin receptor |
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| Research Abstract |
HCII+/- mice we generated had about 60% of plasma HCII activity. Cuff placement around femoral artery for 4 weeks caused prominent neointimal and adventitial hyperplasia with augmented expression of protease-activated receptor 1 in HCII+/- mice compared with HCII+/+ mice. These exacerbated vascular remodeling was ameliorated to similar level as HCII+/+ mice by administration of purified human HCII protein.
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