2006 Fiscal Year Final Research Report Summary
Research for reconstruction of cortico-spinal motor control system which related to functional recovery from central motor disturbances.
| Project/Area Number |
16590820
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Shinshu University |
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Principal Investigator |
MORITA Hiroshi Shinshu University Hospital, Department of Medicine (Neurology & Rheumatology), Assistant professor, 医学部附属病院, 講師 (10262718)
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| Project Period (FY) |
2004 – 2006
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| Keywords | Parkinson's disease / Spasticity / Spinal reflex / Tendon tap reflex / alpha-gamma co-activation / Ib inhibition / Conversion disorder |
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| Research Abstract |
Neurophysiological relationship between motor control disturbances and abnormality of cortico-spinal motor control system was investigated using, H-reflex, Tendon tap reflex, transcranial magnetic stimulation (TMS) in patients with motor disturbance due to Parkinson's disease(PD), spasticity and conversion disorders (CD).
In patients with PD, we investigated the difference of modulation of reflexes with voluntary contraction between H-reflex and Tendon tap reflexes. In PD, the size of H-reflex increased with tonic plantarflexion as in normal subjects, but T-reflex decreased. These changes in T-reflex were correlated with the grade of rigidity, bradykinesia, and time for 10m gait. Inappropriate supraspinal modulation of the spinal reflex pathways may disturb motor performance in PD.
In patients with spasticity we investigated modulation of Ib inhibition on soleus H-reflex during tonic dorsiflexion. In the resting state, the extent of Ib inhibition in the patients with spasticity did not d
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iffer from normal controls. During antagonist contraction, the extent of inhibition increased both in the normal subjects and patients. But the increment was smaller in the patients, especially in those with severe spastic gait. The smaller increment in the inhibition was correlated with the time required to walk 10 m. Disturbed central modulation of non-reciprocal (Ib) interneurons may be responsible for spasticity.
In patients with motor palsy due to CD, we evaluated variance of size of motor evoked potentials among trials at the onset of voluntary effort for contraction as coefficient of variance (CV) of size of motor evoked potential evoked with TMS. CV in the patients was larger in patients with CD than in controls. The variance among trials may reflect variance in internal voluntary effort at the onset of contraction, regardless of whether this was intentional or unconscious. We conclude that the size variance among MEP trials with cue signal is a supportive parameter for the diagnosing CD. Less
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