2005 Fiscal Year Final Research Report Summary
Genome-wide association study of susceptibility genes for Graves' disease
| Project/Area Number |
16590903
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Kyoto University |
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Principal Investigator |
KOSUGI Shinji Kyoto University, Graduate School of Medicine, Professor, 医学研究科, 教授 (50252432)
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| Co-Investigator(Kenkyū-buntansha) |
INOKO Hidetoshi Tokai University, School of Medicine, Professor, 医学部, 教授 (10101932)
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| Project Period (FY) |
2004 – 2005
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| Keywords | Multi-factorial disease / disease-susceptibility gene / pooled DNA method / microsatellite / association study / case-control study |
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| Research Abstract |
We performed genetic analysis of Graves' disease. Association study of susceptibility genes for Graves' disease using 30,000 microsatellite markers distributed in the entire genome was done with 200 Graves' samples and 200 healthy controls. 14% markers were statistically significantly different between cases and controls. Those were tested with different samples as second screening. 1.5% markers were statistically significant and will be re-examined in the third screening.
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[Journal Article] Polymorphisms in PTCH1 Affect the Risk of Ameloblastoma2005
Author(s)
T.Kawabata, K.Takahashi, M.Sugai, A.Murashima-Suginami, S.Ando, A.Shimizu, S.Kosugi, T.Sato, M.Nishida, K.Murakami, T.Iizuka
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Journal Title
J Dent Res 84(9)
Pages: 812-816
Description
「研究成果報告書概要(欧文)」より
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