2006 Fiscal Year Final Research Report Summary
Therapeutic mechanism of vitamin B12 on sleep wake-rhythm disorders
| Project/Area Number |
16591165
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
ITOH Hiroshi Jikei University, School of medicine, Assistant professor, 医学部, 助教授 (20151532)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADERA Wataru Jikei University, School of medicine, Lecturer, 医学部, 講師 (50230496)
OZONE Motohiro Jikei University, School of medicine, Lecturer, 医学部, 講師 (50246386)
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| Project Period (FY) |
2004 – 2006
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| Keywords | vitamine B12 / CAP(cyclic alternating pattern) / PVT (Psychomotor vigilance task) / sleep stability / VAS (Visual analog scale) / Psychophysiological insomnia |
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| Research Abstract |
Our goal of this study was to clarify the therapeutic mechanism of B12 on sleep in insomniacs by means of polysomnograghy (PSG) using cyclic alternative pattern (CAP) method.
Step 1
1. Subjects : 8 male normal subjects (mean age;36.5±11.2y)
2. Drug : methylcobalamine(B12) 500μg i.v. or saline (placebo) 1ml i.v. (23:00)
3. Measurements
1) Plasma concentration of B12 (23:00,8:00)
2) PSG(0:00-7:30. PSG data were analyzed visually using conventional and CAP method)
3) Psychomotor vigilance task (PVT)
4) Visual analog scale (VAS)
3),4) items were performed 8:00,9:00,11:00, and 13:00 next morning after PSG test.
4. Results
By the administration of B12...
1) Concentration of B12 significantly increased. (280.0±90.1→1876.7±1327.3pg/ml, p<0.05)
2) Sleep parameters were not statically changed.
3) CAP rate was significantly decreased. (37.1±14.6→31.1±15.1%,p=0.0499)
Step 2
1. Subjects: 8 female insomnia patients (mean age;36.5±11.2y), who met the diagnosis of psychophysiological insomnia (PPI) in ICSD-I.
2. Drug and Measurements : the same as those of Step 1
3. Results
By the administration of B12...
1) Concentration of B12 significantly increased.
2) Sleep parameters were not statically changed.
3) CAP time, CAP rate, the number of CAP cycles, and the number of subtype Al were significantly decreased. (CAP rate:62.6 ±10.3→53.4±10.4%,P=0.028)
4) Subjective sleep quality and PVT variables were not changed next mornings.
Conclusion
From the above-mentioned results, it was reconfirmed that CAP rate in Japanese PPI patients increased (62.6%) as well as those in insomnia patients of oversea.
Furthermore, our findings suggested that peripherally infused B12 might have the ability of enforcing sleep stability in insomnia patients. It was also suggested that B12 might act on sleep control system via suppressing subcortical arousal in insomnia patients, because subtype Al was especially decreased.
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