2007 Fiscal Year Final Research Report Summary
The corpus callosum in obsessive-compulsive disorder : a diffusion tensor imaging study
| Project/Area Number |
16591173
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kansai Medical University |
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Principal Investigator |
KINOSHITA Toshihiko Kansai Medical University, Neuropsychiatry, professor (20186290)
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| Co-Investigator(Kenkyū-buntansha) |
OKUGAWA Gaku Kansai Medical University, Neuropsychiatry, associate professor (80343672)
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| Project Period (FY) |
2004 – 2007
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| Keywords | brain・nerve / cranial nerve disease |
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| Research Abstract |
Purpose:
To prospectively examine white matter microstructural abnormalities in the corpus callosum (CC) of OCD patients, as compared with controls, and to investigate the relationship between DTI measures of the CC region and clinical symptoms in OCD.
Materials and Methods :
Institutional review board approval was obtained, and each participant (or parents) provided written informed consent. 16 patients with OCD (7 men, 9 women; mean±SD age, 28.7±9.8) and matched control subjects (7 men, 9 women; mean±SD age, 29.9±9.0). Mean diffusivity (MD) and fractional anisotropy (FA) were measured in the five subdivisions of the CC. Paired t test was used to compare MD or FA of CC regions from patients with OCD and controls.
Results :
There were no significant differences (rostrum, p=0.15; genu, p=0.88; rostral body, p=0.12; isthmus, p=0.77; splenium, p=0.88) of MD between patients with OCD and healthy volunteers. A significant reduction in FA was found in the rostrum of the CC of patients with OCD compared with that of controls (P < 0.001). Higher FA only in the rostrum correlated significantly with lower Y-BOCS scores (r=-0.72, p=0.002).
Conclusions :
Our results support the widely held view that the orbital prefrontal region is involved in the pathophysiology of OCD and also imply involvement of the orbitofrontal circuit in symptom severity in OCD patients.
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Research Products
(8 results)
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[Presentation] 1 Department of Neuropsychiatry ; 2 Department of Radiology, Kansai Medical University, Osaka, JapanWHITE MATTER ABNORMALITIES IN OBSESSIVE-COMPULSIVE DISORDER A DIFFUSION TENSOR IMAGING STUDY2007
Author(s)
Y. Saito^1, K. Nobuhara^1, G. Okugawa^1, K. Takase^1, T. Sugimoto^1, K. Ikeda^2, S. Sawada^2, T. Kinoshita^1
Organizer
29th Japanese Society of Biological Psychiatry
Place of Presentation
Hokkaido, Japan
Year and Date
2007-07-13
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 1 Department of Neuropsychiatry ; 2 Department of Radiology, Kansai Medical University, Osaka, JapanWHITE MATTER ABNORMALITIES IN OBSESSIVE-COMPULSIVE DISORDER2006
Author(s)
Y. Saito^1, K. Nobuhara^1, G. Okugawa^1, K. Takase^1, T. Sugimoto^1, K. Ikeda^2, S. Sawada^2, T. Kinoshita^1
Organizer
28th Japanese Society of Biological Psychiatry
Place of Presentation
Nagoya, Japan
Year and Date
2006-09-16
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 1 Department of Neuropsychiatry ; 2 Department of Radiology, Kansai Medical University, Osaka, JapanTHE CORPUS CALLOSUM IN OBSESSIVE-COMPULSIVE DISORDER A DIFFUSION TENSOR IMAGING STUDY2006
Author(s)
Y. Saito^1, K. Nobuhara^1, G. Okugawa^1, K. Takase^1, T. Sugimoto^1, K. Ikeda^2, S. Sawada^2, T. Kinoshita^l
Organizer
14th Association of European Psychiatrists Congress
Place of Presentation
France
Year and Date
2006-03-07
Description
「研究成果報告書概要(欧文)」より
