Tamoxifen activates CYP3A4 and MDR-1 genes through steroid and xenobiotic receptor in breast cancer cells.

2005 Fiscal Year Final Research Report Summary

• Project/Area Number: 16591247
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Gunma University
• Principal Investigator: KOIBUCHI Yukio GUNMA UNIVERSITY, SCHOOL OF MEDICINE, DEPT.THRACIC AND VISCERAL ORGAN SURGERY, INVESTIGATOR, 医学部, 助手 (10323346)
• Co-Investigator(Kenkyū-buntansha): IINO Yuichi GUNMA UNIVERSITY, GRAD.SCHL.MED., DEPT.EMERGENCY MEDICINE, PROFESSOR, 医学系研究科, 教授 (50124649) ; HORIGUCHI Jun , 医学部, 講師 (70272242) ; KOIBUCHI Noriyuki GUNMA UNIVERSITY, GRAD.SCHL.MED., DEPT.INTEGRATIVE PHYSIOLOGY, PROFESSOR, 医学系研究科, 教授 (80234681) ; IWASAKI Toshiharu GUNMA UNIVERSITY, GRAD.SCHL.MED., DEPT.INTEGRATIVE PHYSIOLOGY, ASSISTANT PROFESSOR, 医学系研究科, 講師 (80375576)
• Project Period (FY): 2004 – 2005
• Keywords: TAMOXIFEN / SXR / HORMONAL THERAPY / CYTOCHROME P450 3A4 / BREAST CANCER / MDR-1

Research Abstract

Cytochrome P450 monooxygenase 3A4 (CYP3A4) is responsible for the metabolism of endogenous steroids, prescribed drugs and xenobiotics. P-glycoprotein, encoded by multidrug resistance 1 (MDR1) gene, functions as an efflux pump transporting substances from inside of the intestinal cells to the lumen to be absorbed or eliminated. Both genes are regulated by steroid and xenobiotic receptor (SXR), a member of nuclear hormone receptor superfamily. Various endogeneous steroids and drugs function as ligands of SXR. Although CYP3A4, MDR1 and SXR are expressed mainly in the liver and the small intestine, these genes are also expressed in breast cancer cells such as MCF-7 cells. Since tamoxifen (TAM), an antiestrogen used for breast cancer treatment, may be involved in SXR-mediated transcription and is known to be metabolized by CYP3A4 and P-glycoprotein, we investigated the effect of TAM on these SXR targeted genes in breast cancer cell lines. Transient transfection-based reporter gene assays showed 4-hydroxy TAM as well as TAM activated the SXR-mediated transcription through CYP3A4 and MDR1 promoters in a ligand- and receptor concentration-dependent manner. We confirmed the binding of 4-hydroxy-TAM to SXR by ligand binding assay. Moreover, semi-quantitative RT-PCR studies revealed that 4-hydroxy TAM activated the expression of CYP3A4 and MDR1 mRNA in MCF-7 cells. These results suggest that TAM induces CYP3A4 and MDR1 gene expression through SXR, which reduces TAM concentration in breast cancer cells. Thus, the expression of SXR in breast cancer cells could be a potential risk factor, which may induce local TAM resistance.

Research Products

• [Journal Article] Significance of local recurrence as a prognostic factor in the treatment of breast cancer (2006)
  • Author(s): Horiguchi J, Koibuchi Y, Yoshida T, Takata D, Kikuchi M, Rokutanda N, Nagaoka R, Iino Y, Sakurai H, Morishita Y
  • Journal Title: Anticancer Res 26 Pages: 569-573
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Significance of local recurrence as a prognostic factor in the treatment of breast cancer. (2006)
  • Author(s): Horiguchi J, Koibuchi Y, Yoshida T, Takata D, Kikuchi M, Rokutanda N, Nagaoka R, Iino Y, Sakurai H, Morishita Y
  • Journal Title: Anticancer Res 26(in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Advanced gastric cancer with peritoneal dissemination successfully treated with paclitaxel and doxifluridine : a case report (2005)
  • Author(s): Takeyoshi I, Iwanami K, Yamada T, Kawate S, Hamada K, Sunose Y, Yoshida M, Horiguchi J, Ohwada S, Sasaki A, Morishita Y
  • Journal Title: Hepatogastroenterology 52 Pages: 322-325
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Inhibitory effects of OK-432 (Picibanil) on cellular proliferation and adhesive capacity of breast carcinoma cells (2005)
  • Author(s): Horii Y, Iino Y, Maemura M, Horiguchi J, Morishita Y
  • Journal Title: Oncol Rep 13 Pages: 289-294
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] HER2 陽性転移性乳癌に対する trastuzumab と paclitaxel併用療法の有用性の検討 (2005)
  • Author(s): 吉田 崇, 堀口 淳, 鯉淵幸生, 狩野貴之, 飯島耕太郎, 菊地麻美, 高他大輔, 六反田奈和, 長岡りん, 佐藤亜矢子, 飯野佑一, 森下靖雄
  • Journal Title: 乳癌の臨 20 Pages: 70-74
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] HER2 陽性転移性乳癌に対する trastuzumab 単独療法の有用性の検討 (2005)
  • Author(s): 吉田 崇, 堀口 淳, 鯉淵幸生, 狩野貴之, 飯島耕太郎, 菊地麻美, 高他大輔, 長岡りん, 六反田奈和, 佐藤亜矢子, 飯野佑一, 森下靖雄
  • Journal Title: 乳癌の臨 20 Pages: 75-78
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A combination phase I study of weekly paclitaxel and doxifluridine in advanced gastric cancer patients (2005)
  • Author(s): Takeyoshi I, Makita F, Tanahashi Y, Yokomori T, Iwazaki S, Kawashima Y, Iwanami K, Yamada T, Kawate S, Hamada K, Sunose Y, Yoshida M, Horiguchi J, Iesato H, Kobayashi M, Morishita Y
  • Journal Title: Anticancer Res 25 Pages: 1291-1296
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Local control by breast-conserving surgery with nipple resection (2005)
  • Author(s): Horiguchi J, Koibuchi Y, Iijima K, Yoshida T, Takata D, Rokutanda N, Nagaoka R, Oyama T, Iino Y, Sakurai H, Morishita Y
  • Journal Title: Anticancer Res 25 Pages: 2957-2959
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Co-expressed type of ER and HER2 protein as a predictive factor in determining resistance to antiestrogen therapy in patients with ER-positive and HER-2-positive breast cancer (2005)
  • Author(s): Horiguchi J, Koibuchi Y, Iijima K, Yoshida T, Takata D, Rokutanda N, Nagaoka R, Oyama T, Iino Y, Morishita Y
  • Journal Title: Oncol Rep 14 Pages: 1109-1116
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] NO donor ameliorates ischemia-reperfusion injury of the rat liver with iNOS attenuation (2005)
  • Author(s): Kurabayashi M, Takeyoshi I, Yoshinari D, Koibuchi Y, Ohki T, Matsumoto K, Morishita Y
  • Journal Title: J Invest Surg 18 Pages: 193-200
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Synovial Sarcoma Translocation (SYT) encodes a nuclear receptor coactivator (2005)
  • Author(s): Iwasaki T, Koibuchi N, Chin WW
  • Journal Title: Endocrinology 146 Pages: 3892-9
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Regulation of brain development by thyroid hormone and its modulation by environmental chemicals (2005)
  • Author(s): Koibuchi N, Iwasaki T
  • Journal Title: Endocrine J (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 甲状腺ホルモンの中枢作用に及ぼす内分泌かく乱物質の影響 (2005)
  • Author(s): 鯉淵典之, 岩崎俊晴, 宮崎 航, 岡田淳一, 下川哲昭, 竹下 章, 黒田洋一郎
  • Journal Title: ホルモンと臨床 53 Pages: 75-80
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein (2005)
  • Author(s): Gray SG, Iglesias AH, Lizcano F, Villanueva R, Camelo S, Jingu H, The BT, Koibuchi N, Chin WW, Kokkotou E, Dangond F
  • Journal Title: J Biol Chem 280 Pages: 28507-18
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Monitoring synaptogenesis in the developing mouse cerebellum with an original oligonucleotide microarray (2005)
  • Author(s): Takahashi M, Kondoh Y, Tashiro H, Koibuchi N, Kuroda Y, Tashiro T
  • Journal Title: J Neurosci Res. 80 Pages: 777-88
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Polychlorinated biphenyl (PCB) alters acid-sensitivity of cultured neurons derived from the medulla oblongata. (2005)
  • Author(s): Okada J, Shimokawa N, Koibuchi N
  • Journal Title: Int J Biochem Cell Biol 37 Pages: 1368-74
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Postnatal changes of steroid receptor coactivator-1 immunoreactivity in rat cerebellar cortex (2005)
  • Author(s): Yousefi B, Jingu H, Ohta M, Umezu M, Koibuchi N
  • Journal Title: Thyroid 15 Pages: 314-9
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Differential expression of p160 steroid receptor coactivators in the rat testis and epididymis. (2005)
  • Author(s): Igarashi-Migitaka J, Takeshita A, Koibuchi N, Yamada S, Ohtani-Kaneko R, Kazuaki Hirata K
  • Journal Title: Eur J Endocrinol 153 Pages: 595-604
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The Interaction of TR{beta}1-N Terminus with Steroid Receptor Coactivator-1 (SRC-1) Serves a Full Transcriptional Activation Function of SRC-1 (2005)
  • Author(s): Iwasaki T, Takeshita A, Miyazaki W, Chin WW, Koibuchi N
  • Journal Title: Endocrinology 147 Pages: 1452-7
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Low dose hydroxylated PCB induces c-Jun expression in PC12 cells (2005)
  • Author(s): Shimikawa N, Miyazaki W, Iwasaki T, Koibuchi N
  • Journal Title: Neurotoxicology 27 Pages: 176-83
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator. (2005)
  • Author(s): Iwasaki T, Koibuchi N, Chin WW
  • Journal Title: Endocrinology 146 Pages: 3892-9
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Postnatal changes of steroid receptor coactivator-1 immunoreactivity in rat cerebellar cortex (2005)
  • Author(s): Yousei B, Jingu H, Ohta M, Umezu M, Koibuchi N
  • Journal Title: Thyroid 15 Pages: 314-9
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Polychlorinated biphenyl (PCB) alters acid-sensitivity of cultured neurons derived from the medulla oblongata (2005)
  • Author(s): Okada J, Shimokawa N, Koibuchi N
  • Journal Title: Int J Biochem Cell Biol 37 Pages: 1368-74
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Retinoid-related receptor (ROR) □ mRNA expression is altered in the brain of male mice lacking all ligand-binding thyroid hormone receptor (TR) isoforms (2005)
  • Author(s): Vasudevan N, Kia HK, Hadjimarkou M, Koibuchi N, Chin WW, Forrest D, Vennstrom B, Pfaff DW
  • Journal Title: Endocrine 26 Pages: 25-32
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Monitoring synaptogenesis in the developing mouse cerebellum with an original oligonucleotide microarray (2005)
  • Author(s): Takahashi M, Kondoh Y, Tashiro H, Koibuchi N, Kuroda Y, Tashiro T
  • Journal Title: J Neurosci Res 80 Pages: 777-788
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Functional characterization of JMJD2A, a histone deacetlyase- and retinoblastoma-binding protein (2005)
  • Author(s): Grey SG, Iglesias AH, Lizcano F, Villanueva R, Camelo S, Jingu H, Teh BT, Koibuchi N, Chin WW, Kokkotou E, Dangond F
  • Journal Title: J Biol Chem 280 Pages: 28507-28518
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Differential expression of p160 steroid receptor coactivators in the rat testis and epididymis (2005)
  • Author(s): Igarashi-Migitaka J, Takeshita A, Koibuchi N, Yamada S, Ohtani-Kaneko R, Hirata K
  • Journal Title: Eur J Endocrinol 153 Pages: 595-604
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 甲状腺ホルモンの中枢作用に及ぼす内分泌かく乱物質の影響 (2005)
  • Author(s): 鯉淵典之, 岩崎俊晴, 宮崎航, 岡田淳一, 下川哲昭, 竹下彰, 黒田洋一郎
  • Journal Title: ホルモンと臨床 53 Pages: 75-80
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 臨床分子内分泌学3 -甲状腺・副甲状腺・骨内分泌代謝系-I. 甲状腺ホルモン 薬理作用と生理差量 脳の発達と機能維持に対する作用 (2005)
  • Author(s): 鯉淵典之
  • Journal Title: 日本臨床(増刊10) 63 Pages: 78-83
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 小脳の疾患と治療 甲状腺ホルモンと小脳障害 (2005)
  • Author(s): 鯉淵典之
  • Journal Title: Clinical Neurosecience 23 Pages: 1419-1421
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Advanced gastric cancer with peritoneal dissemination successfully treated with paclitaxel and doxifluridine : a case report. (2005)
  • Author(s): Takeyoshi I, Iwanami K, Yamada T, Kawate S, Hamada K, Sunose Y, Yoshida M, Horiguchi J, Ohwada S, Sasaki A, Morishita Y
  • Journal Title: Hepatogastroenterology 52 Pages: 322-325
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inhibitory effects of OK-432 (Picibanil) on cellular proliferation and adhesive capacity of breast carcinoma cells. (2005)
  • Author(s): Horii Y, Iino Y, Maemura M, Horiguchi J, Morishita Y
  • Journal Title: Oncol Rep 13 Pages: 289-294
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A combination phase I study of weekly paclitaxel and doxifluridine in advanced gastric cancer patients. (2005)
  • Author(s): Takeyoshi I, Makita F, Tanahashi Y, Yokomori T, Iwazaki S, Kawashima Y, Iwanami K, Yamada T, Kawate S, Hamada K, Sunose Y, Yoshida M, Horiguchi J, Iesato H, Kobayashi M, Morishita Y
  • Journal Title: Anticancer Res 25 Pages: 1291-1296
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Local control by breast-conserving surgery with nipple resection. (2005)
  • Author(s): Horiguchi J, Koibuchi Y, Iijima K, Yoshida T, Takata D, Rokutanda N, Nagaoka R, Oyama T, Iino Y, Sakurai H, Morishita Y
  • Journal Title: Anticancer Res 25 Pages: 2957-2959
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Co-expressed type of ER and HER2 protein as a predictive factor in determining resistance to antiestrogen therapy in patients with ER-positive and HER-2-positive breast cancer. (2005)
  • Author(s): Horiguchi J, Koibuchi Y, Iijima K, Yoshida T, Takata D, Rokutanda N, Nagaoka R, Oyama T, Iino Y, Morishita Y
  • Journal Title: Oncol Rep 14 Pages: 1109-1116
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] NO donor ameliorates ischemia-reperfusion injury of the rat liver with iNOS attenuation. (2005)
  • Author(s): Kurabayashi M, Takeyoshi I, Yoshinari D, Koibuchi Y, Ohki T, Matsumoto K, Morishita Y
  • Journal Title: J Invest Surg. 18 Pages: 193-200
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Synovial Sarcoma Translocation (SYT) encodes a nuclear receptor coactivator. (2005)
  • Author(s): Iwasaki T, Koibuchi N, Chin WW
  • Journal Title: Endocrinology 146 Pages: 3892-3899
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Regulation of brain development by thyroid hormone and its modulation by environmental chemicals. (2005)
  • Author(s): Koibuchi N, Iwasaki T
  • Journal Title: Endocrine J
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. (2005)
  • Author(s): Gray SG, Iglesias AH, Lizcano F, Villanueva R, Camelo S, Jingu H, The BT, Koibuchi N, Chin WW, Kokkotou E, Dangond F
  • Journal Title: J Biol Chem. 280 Pages: 28507-28518
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Monitoring synaptogenesis in the developing mouse cerebellum with an original oligonucleotide microarray. (2005)
  • Author(s): Takahashi M, Kondoh Y, Tashiro H, Koibuchi N, Kuroda Y, Tashiro T
  • Journal Title: J Neurosci Res. 80 Pages: 777-788
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Polychlorinated biphenyl (PCB) alters acid-sensitivity of cultured neurons derived from the medulla oblongata. (2005)
  • Author(s): Okada J, Shimokawa N, Koibuchi N
  • Journal Title: Int J Biochem Cell Biol. 37 Pages: 1368-1374
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Postnatal changes of steroid receptor coactivator-1 immunoreactivity in rat cerebellar cortex. (2005)
  • Author(s): Yousefi B, Jingu H, Ohta M, Umezu M, Koibuchi N
  • Journal Title: Thyroid 15 Pages: 314-319
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Differential expression of p160 steroid receptor coactivators in the rat testis and epididymis. (2005)
  • Author(s): Igarashi-Migitaka J, Takeshita A, Koibuchi N, Yamada S, Ohtani-Kaneko R, Kazuaki Hirata K
  • Journal Title: Eur J Endocrinol. 153 Pages: 595-604
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The Interaction of TR{beta}1-N Terminus with Steroid Receptor Coactivator-1 (SRC-1) Serves a Full Transcriptional Activation Function of SRC-1. (2005)
  • Author(s): Iwasaki T, Takeshita A, Miyazaki W, Chin WW, Koibuchi N
  • Journal Title: Endocrinology 147 Pages: 1452-1457
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Low dose hydroxylated PCB induces c-Jun expression in PC12 cells. (2005)
  • Author(s): Shimikawa N, Miyazaki W, Iwasaki T, Koibuchi N
  • Journal Title: Neurotoxicology 27 Pages: 176-183
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Postnatal changes of steroid receptor coactivator-1 immunoreactivity in rat cerebellar cortex. (2005)
  • Author(s): Yousei B, Jingu H, Ohta M, Umezu M, Koibuchi N
  • Journal Title: Thyroid 15 Pages: 314-319
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Retinoid-related receptor (ROR)□ mRNA expression is altered in the brain of male mice lacking all ligand-binding thyroid hormone receptor (TR) isoforms. (2005)
  • Author(s): Vasudevan N, Kia HK, Hadjimarkou M, Koibuchi N, Chin WW, Forrest D, Vennstrom B, Pfaff DW
  • Journal Title: Endocrine 26 Pages: 25-32
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Monitoring synaptogenesis in the developing mouse cerebellum with an original oligonucleotide microarray. (2005)
  • Author(s): Takahashi M, Kondoh Y, Tashiro H, Koibuchi N, Kuroda Y, Tashiro T
  • Journal Title: J Neurosci Res 80 Pages: 777-788
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Functional characterization of JMJD2A, a histone deacetlyase- and retinoblastoma-binding protein. (2005)
  • Author(s): Grey SG, Iglesias AH, Lizcano F, Villanueva R, Camelo S, Jingu H, Teh BT, Koibuchi N, Chin WW, Kokkotou E, Dangond F
  • Journal Title: J Biol Chem 280 Pages: 28507-28518
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Differential expression of p160 steroid receptor coactivators in the rat testis and epididymis. (2005)
  • Author(s): Igarashi-Migitaka J, Takeshita A, Koibuchi N, Yamada S, Ohtani-Kaneko R, Hirata K
  • Journal Title: Eur J Endocrinol 153 Pages: 595-604
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] DPD activity and DPD expression (2004)
  • Author(s): Horiguchi J, Yoshida T, Koibuchi Y, Iijima K, Ninomiya J, Takei H, Yokoe T, Iino Y, Morishita Y
  • Journal Title: Oncol Rep 11 Pages: 65-72
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Immunohistochemical analysis of 14-3-3 sigma and related protein in hyperplastic and neoplastic breast lesions, with particular reference to early carcinogenesis (2004)
  • Author(s): Simooka H, Oyama T, Sano T, Horiguchi J, Nakajima T
  • Journal Title: Pathol Int 54 Pages: 595-602
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 病理診断における分子生物学 : 診断への応用と展望 : 腫瘍 : 乳癌. (2004)
  • Author(s): 小山徹也, 下岡華子, 堀口 淳
  • Journal Title: 病理と臨床 22 Pages: 156-163
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 乳腺微細石灰化症例のマンモグラフィ所見との対比による病理学的検討 (2004)
  • Author(s): 小山徹也, 下岡華子, 飯島耕太郎, 吉田美穂, 二宮 淳, 鯉淵幸生, 堀口 淳, 横江隆夫, 飯野佑一
  • Journal Title: 日乳癌検診学会誌 13 Pages: 154-157
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 乳腺の過形成および腫瘍性病変における 14-3-3 シグマと関連蛋白の免疫組織学的検討-とくに癌化過程早期について- (2004)
  • Author(s): 小山徹也, 下岡華子, 中島 孝, 戸谷裕之, 飯島耕太郎, 鯉淵幸生, 堀口 淳, 飯野佑一
  • Journal Title: 乳癌基礎研究 13 Pages: 11-15
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 乳癌センチネルリンパ節生検-色素法と色素・RI併用法の比較検討- (2004)
  • Author(s): 堀口 淳, 鯉淵幸生, 吉田 崇, 飯島耕太郎, 高他大輔, 長岡りん, 六反田奈和, 小山徹也, 中島 孝, 織内 昇, 遠藤啓吾, 飯野佑一, 森下靖雄
  • Journal Title: Kitakanto Med J 54 Pages: 105-108
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Metastatic breast cancer treated with trastuzumab and paclitaxel-a case report with clinically complete response (2004)
  • Author(s): Yosida T, Horiguchi J, Koibuchi Y, Kanoh T, Iijima K, Yoshida M, Kikuchi M, TAkata D, Oyama T, Iino Y, Morishita Y
  • Journal Title: Gan to Kagaku Ryoho 31 Pages: 907-910
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] GnRH アンタゴニストの臨床応用-乳癌- (2004)
  • Author(s): 飯野佑一, 鯉淵幸生
  • Journal Title: 産科と婦人科 71 Pages: 321-326
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Core needle biopsy (CNB) as a diagnostic method for breast lesions : comparison with fine needle aspiration cytology (FNA) (2004)
  • Author(s): Oyama T, Koibuchi Y, McKee G
  • Journal Title: Breast Cancer 11 Pages: 339-42
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Polychlorinated biphenyls suppress thyroid hormone-mediated transcription.through a novel mechanism. (2004)
  • Author(s): Miyazaki W, Iwasaki T, Takeshita A, Kuroda Y, Koibuchi N
  • Journal Title: J. Biol. Chem 279 Pages: 18195-202
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 内分泌かく乱物質の甲状腺ホルモン系への影響 (2004)
  • Author(s): 鯉淵典之, 岩崎俊晴
  • Journal Title: 現代科学 396 Pages: 62-66
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Impact of thyroid hormone deficiency on the developing CNS : cerebellar glial and neuronal protein expression in rat neonates exposed to antithyroid drug propylthiouracil (2004)
  • Author(s): Li GH, Post J, Koibuchi N, Sajdel-Sulkowska EM
  • Journal Title: Cerebellum 3 Pages: 100-106
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] DPD activity and DPD expression. (2004)
  • Author(s): Horiguchi J, Yoshida T, Koibuchi Y, Iijima K, Ninomiya J, Takei H, Yokoe T, Iino Y, Morishita Y
  • Journal Title: Oncol Rep 11 Pages: 65-72
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Immunohistochemical analysis of 14-3-3 sigma and related protein in hyperplastic and neoplastic breast lesions, with particular reference to early carcinogenesis. (2004)
  • Author(s): Simooka H, Oyama T, Sano T, Horiguchi J, Nakajima T
  • Journal Title: Pathol Int 54 Pages: 595-602
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Metastatic breast cancer treated with trastuzumab and paclitaxel-a case report with clinically complete response. (2004)
  • Author(s): Yosida T, Horiguchi J, Koibuchi Y, Kanoh T, Iijima K, Yoshida M, Kikuchi M, TAkata D, Oyama T, Iino Y, Morishita Y
  • Journal Title: Gan to Kagaku Ryoho 31 Pages: 907-910
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Core needle biopsy (CNB) as a diagnostic method for breast lesions : comparison with fine needle aspiration cytology (FNA). (2004)
  • Author(s): Oyama T, Koibuchi Y, McKee G
  • Journal Title: Breast Cancer 11 Pages: 339-342
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Polychlorinated biphenyls suppress thyroid hormone-mediated transcription. through a novel mechanism. (2004)
  • Author(s): Miyazaki W, Iwasaki T, Takeshita A, Kuroda Y, Koibuchi N
  • Journal Title: J.Biol.Chem. 279 Pages: 18195-18202
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Impact of thyroid hormone deficiency on the developing CNS : cerebellar glial and neuronal protein expression in rat neonates exposed to antithyroid drug propylthiouracil. (2004)
  • Author(s): Li GH, Post J, Koibuchi N, Sajdel-Sulkowska EM
  • Journal Title: Cerebellum 3 Pages: 100-106
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] 炎症性乳癌が疑われた乳腺血管炎の一例. 良性乳腺疾患アトラス,乳腺診療の手引き (弥生恵司、井内康輝,編集) (2005)
  • Author(s): 吉田美穂, 武井寛幸, 堀口 淳
  • Total Pages: 220-221
  • Publisher: 永井書店
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 炎症性乳がん. 乳がん患者へのトータルアプローチ (射場典子,長瀬慈村,監修) (2005)
  • Author(s): 堀口 淳
  • Total Pages: 90-91
  • Publisher: ピラールプレス
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 下胸筋神経・血管の温存. 乳腺外科の要点と盲点(霞 富士雄編集) (2005)
  • Author(s): 堀口 淳
  • Total Pages: 202-203
  • Publisher: 文光堂
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 甲状腺の発達と脳機能-内分泌撹乱の蓋然性- In : 生体統御システムと内分泌撹乱(井口,井上編) (2005)
  • Author(s): 鯉淵典之
  • Total Pages: 105-115
  • Publisher: シュプリンガー・フェアラーク
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Nuclear hormone receptor and its cofactors. (2005)
  • Author(s): Iwasaki T, Koibuchi N
  • Total Pages: 173-190
  • Publisher: Fundamentos moleculares en medicina
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 変わり始めたtamoxifenの投与法.乳癌診療二頁の秘訣(光山昌珠,編集) (2004)
  • Author(s): 鯉淵幸生
  • Total Pages: 266-267
  • Publisher: 金原出版
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 再発乳癌-高カルシウム血症の診断と治療.(別冊) 医学のあゆみ. 乳腺疾患 (伊藤良則,戸井雅和編) (2004)
  • Author(s): 鯉淵幸生
  • Total Pages: 445-447
  • Publisher: 医歯薬出版
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 乳癌化学療法におけるDIFの役割.コンセンサス癌治療(小川道雄ほか,編集) (2004)
  • Author(s): 堀口 淳
  • Total Pages: 48-49
  • Publisher: ヘルス出版
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 針穿刺組織診のコツと落とし穴.乳癌診断のコツと落とし穴(霞富士雄,編集) (2004)
  • Author(s): 堀口 淳
  • Total Pages: 127
  • Publisher: 中山書店
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 乳房温存手術において切除断端を陰性にする工夫. 乳癌診療二頁の秘訣 (光山昌珠,編集) (2004)
  • Author(s): 堀口 淳
  • Total Pages: 158-159
  • Publisher: 金原出版
  • Description: 「研究成果報告書概要(和文)」より