Study of drug sensitivity to molecular targeting drugs in breast cancer

2006 Fiscal Year Final Research Report Summary

• Project/Area Number: 16591282
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Kurume University
• Principal Investigator: FUJII Teruhiko Kurume University, Medical School, Associate Professor, 医学部, 助教授 (50199288)
• Co-Investigator(Kenkyū-buntansha): YOKOYAMA Goro Kurume University, Medical School, Research Associate, 医学部, 助手 (00309808) ; YAMAGUCHI Miki Kurume University, Medical School, Research Associate, 医学部, 助手 (70330834) ; KUWANO Michihiko Kurume University, Medical School, Professor, 医学部, 教授 (80037431)
• Project Period (FY): 2004 – 2006
• Keywords: breast cancer / YB-1 / Cap43

Research Abstract

1. Expression of nuclear YB-1 thus may play an essential role in acquirement of malignant characteristics through HER2-Akt dependent pathways in breast cancer patients. Nuclear YB-1 localization would thus be expected to be molecular target of intrinsic importance not only for acquirement of multidrug resistance but also for tumor growth dependent upon HER2 and estrogen receptor.
2. Estradiol-induced down-regulation of Cap43 gene thus appeared to be mediated through ER-α dependent pathway in breast cancer cells in culture and in patients. Cap43 will be a molecular marker useful for determination of the therapeutic efficacy of anti-estrogenic anticancer agents in breast cancer.

Research Products

• [Journal Article] Down-regulation of Cap43/NDRGI/Drg-1, a Putative Differentiation-related and Metastasis Suppressor Gene, in Human Breast Cancer Cells. (2006)
  • Author(s): Fotovati A et al.
  • Journal Title: Clin Cancer Res 12 Pages: 3010-3018
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Activation of protein Kinase C δ induces growth arrest in NPA thyroid cancer cells through extracellular signal-regulated kinase mitogen-activated protein kinase. (2006)
  • Author(s): Koike K et al.
  • Journal Title: Thyroid 16 Pages: 333-341
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Characterization of IL-2-activated TILs and their use for Intrapericardial Immunotherapy in Malignant Pericardial Effusion. (2006)
  • Author(s): Toh U et al.
  • Journal Title: Cancer Immunol Immun 55 Pages: 1219-1227
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Characterization of IL-2-activated TILs and their use for Intrapericardial Immunotherapy in Malignant Pericardial Effusion. (2006)
  • Author(s): Toh U, Fujii T, Seki N, Niiya F, Shirouzu K, Yamana H.
  • Journal Title: Cancer Immunol Immun 55 Pages: 1219-1227
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Activation of protein Kinase C δ induces growth arrest in NPA thyroid cancer cells through extracellular signal-regulated kinase mitogen-activated protein kinase. (2006)
  • Author(s): Koike K, Fujii T, Nakamura AM, Yokoyama G, Yamana H, Kuwano M, Shirouzu K.
  • Journal Title: Thyroid 16 Pages: 333-341
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 17P-Estradiol Induces Down-regulation of Cap43/NDRG1/Drg-1, a Putative Differentiation-related and Metastasis Suppressor Gene, in Human Breast Cancer Cells. (2006)
  • Author(s): Fotovati A, Fujii T, Yamaguchi M, Kage M, Shirouzu K, Oie S, Basaki Y, Ono M, Yamana H, Kuwano M.
  • Journal Title: Clin Cancer Res 12 Pages: 3010-3018
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Her2 overexpression increases sensitivity to gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, through inhibition of HER2/HER3 heterodimer formation in lung cancer cells. (2005)
  • Author(s): Hirata A et al.
  • Journal Title: Cancer Res 65 Pages: 4253-4260
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Her2 overexpression increases sensitivity to gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, through inhibition of HER2/HER3 heterodimer formation in lung cancer cells. (2005)
  • Author(s): Hirata A, Hosoi F, Miyagawa M, Ueda S, Naito S, Fujii T, Kuwano M, Ono M.
  • Journal Title: Cancer Res 65 Pages: 4253-4260
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Sensitivity to Gefitinib (Iressa, ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the EGF receptor/ERK1/2 and EGF receptor/Akt pathway for proliferation. (2004)
  • Author(s): Ono M et al.
  • Journal Title: Mol Cancer Ther 3 Pages: 465-472
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The role of nuclear Y-box binding protein 1 as a global marker in drug resistance. (2004)
  • Author(s): Kuwano M et al.
  • Journal Title: Mol Cancer Ther 3 Pages: 1485-1492
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The role of nuclear Y-box binding protein 1 as a global marker in drug resistance. (2004)
  • Author(s): Kuwano M, Oda Y, Izumi H, Yang SJ, Uchiumi T, Iwamoto Y, Toi M, Fujii T, Yamana H, Kinoshita H, Kamura T, Tsuneyoshi M, Yasumoto K, Kohno K.
  • Journal Title: Mol Cancer Ther 3 Pages: 1485-1492
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Sensitivity to Gefitinib (Iressa, ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the EGF receptor/ERK1/2 and EGF receptor/Akt pathway for proliferation. (2004)
  • Author(s): Ono M, Hirata A, Kometani T, Miyagawa M, Ueda S, Kinoshita H, Fujii T, Kuwano M.
  • Journal Title: Mol Cancer Ther 3 Pages: 465-472
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] The critical role of inflammatory cell infiltration in tumor angiogenesis a target for antitumor drug development? (2005)
  • Author(s): Kuwano M et al.
  • Total Pages: 157-170
  • Publisher: "New Angiogenesis Research", Nova Science Publishers, Inc., New York
  • Description: 「研究成果報告書概要(和文)」より