2005 Fiscal Year Final Research Report Summary
Electrophysiological and Pharmacokinetic study for the mechanism of pregnancy-induced analgesia
| Project/Area Number |
16591523
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
IWASAKI Hiroshi Asahikawa Medical College, Professor, 医学部, 教授 (70223386)
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| Co-Investigator(Kenkyū-buntansha) |
FUJITA Satoshi Asahikawa Medical College, Associate Professor, 医学部, 助教授 (10173428)
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| Project Period (FY) |
2004 – 2005
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| Keywords | endogenous analgesia / GABA receptor / NMDA receptor |
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| Research Abstract |
In the present study, we have demonstrated that midazolam has no differential depressant effect on epileptiform activity induced by bicuculline between CA1-PCs and DG-GCs using the MED system in acute hippocampal slices. In contrast, we have previously shown that midazolam has differential depressant effect on the epileptiform activity between CA1-PCs and DG-GCs in the experimentally magnesium-free model, leading to activation of N-methyl-D-aspartate receptor-mediated responses. These results suggest that midazolam selectively differentiates between the synaptic GABAA receptors of these hippocampal neurons.
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Research Products
(4 results)
