2005 Fiscal Year Final Research Report Summary
Medical economics affected by anesthetic methods in liver surgery from the points of view of hepatic hypoxia and bacterial infection.
| Project/Area Number |
16591571
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Fujita Health University |
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Principal Investigator |
KAINUMA Motoshi Fujita Health University, School of Medicine, Professor, 医学部, 教授 (90135335)
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| Co-Investigator(Kenkyū-buntansha) |
KAWASE Kyo Fujita Health University, School of Medicine, Assistant, 医学部, 助手 (30322548)
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| Project Period (FY) |
2004 – 2005
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| Keywords | amesthetic method / hepatic hypoxia / hepatic venous oxygen saturation / epidural anesthesia / general anesthesia / post operative hospital day / medical economics / bacterial infection |
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| Research Abstract |
We anesthetized 90 patients undergoing liver surgery. Anesthetic method was general anesthesia with (46 patients) or without (44 patients) epidural anesthesia using ropivacaine. In patients with epidural anesthesia, mean postoperative hospital days were 41 days in 38 patients anesthetized with nitours oxide, isoflurane and ropivacaine, 37.0 days hi 4 patients with isoflurane and ropivacine, 34.0 days in 3 patients with nitrous oxide, sevoflurane and ropivacaine, and 28.0 days in one patients with sevoflurane and ropiovacaine. In patients without epidural anesthesia, mean postoperative hospital days were 64.3 days in 36 patients anesthetized with nitours oxide, isoflurane and fentanyl, 29.5 days in 4 patients with nitrous oxide, sevoflurane and fentanyl, 48.3 days in 3 patients with isoflurane and fentanyl, and 26.0 days in one patients with nitrous oxide and isoflurane. There was no statistical difference in mean postoperative hospital days among anesthetic methods. However, there was a tendency of shortening in mean postoperative hospital days in patients with epidural anesthesia.
There were also no differences in hepatic hypoxic insult by monitoring hepatic venous hemoglobin oxygen saturation among anesthetic methods.
We made a model to detect bacterial DNA by PCR in the laboratory level, however, found several disadvantages in clinical application. There were also no differences in the frequency of postoperative infection anesthetic methods, however there remains to be the establishment of PCR method for early detection of bacterial DNA in the future.
In conclusion, There was no statistical difference in mean postoperative hospital days among anesthetic methods. However, there was a tendency of shortening in mean postoperative hospital days in patients with epidural anesthesia. Epidual anesthesia together with general anesthesia has possibly some advantages of reducing medical cost, comparing with general anesthesia alone in liver surgery.
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Research Products
(6 results)
