2005 Fiscal Year Final Research Report Summary

Olfactory function on the mouse model for Alzheimer's disease

Research Project

Project/Area Number	16591698
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Otorhinolaryngology
Research Institution	The University of Tokyo
Principal Investigator	TAKEUCHI Naonobu The University of Tokyo, The University of Tokyo Hospital, Assistant Professor (40280945)
Co-Investigator(Kenkyū-buntansha)	KONDO Kenji The University of Tokyo, Hospital, Assistant Professor (40334370)
Project Period (FY)	2004 – 2005
Keywords	Alzheimer's disease / model mouse / olfactory disturbance / tau protein / olfactory epithelium / olfactory bulb / immunohistochemistry
Research Abstract	We investigated the changes of olfactory mucosa and olfactory bulb of a mouse model (transgenic mouse) for Alzheimer's disease. This mouse exhibits over expression of the tau protein in CNS. Immnohistochemical staining was performed with phosphate tau protein antibody (PS199) and bromodeoxyuridine (BrdU). PS199 immunoreactivity was found in the upper part of the olfactory cell layer of the epithelium, olfactory nerve bundles and olfactory bulbs even in mice 8 months after birth. On the other hand, BrdU immunoreactivity was weak in the bottom part of the olfactory cell layer. These results indicate that the changes in the olfactory epithelium and olfactory bulb are similar to those in the CNS of this mouse model. Also, olfactory disturbance may happen in this mouse model.

(4 results)