• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2006 Fiscal Year Final Research Report Summary

The relationship between chewing ability, cognitive function and atherosclerosis in the elderly.

Research Project

Project/Area Number 16592092
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Social dentistry
Research InstitutionKyushu Dental College

Principal Investigator

FUKUHARA Masayo  Kyushu Dental College, Department of Dentistry, Research trainee, 歯学部, 特別研修員 (90360057)

Co-Investigator(Kenkyū-buntansha) ANSAI Toshihiri  Kyushu Dental College, Department of Dentistry, Assistant professor, 歯学部, 助教授 (80244789)
TAKATA Yutaka  Kyushu Dental College, Department of Dentistry, Professor, 歯学部, 教授 (40163208)
AKIFUSA Sumio  Kyushu Dental College, Department of Dentistry, Research trainee, 歯学部, 特別研修員 (40295861)
SONOKI Kazuo  Kyushu Dental College, Department of Dentistry, Assistant professor, 歯学部, 助手 (50316155)
TAKEHARA Tadamichi  Kyushu Dental College, Department of Dentistry, Professor, 歯学部, 教授 (00038879)
Project Period (FY) 2004 – 2006
Keywordselderly / chewing ability / cognitive impairment / mini-mental state examination / pulse wave velocity / arterial stiffness
Research Abstract

Background and Purpose: Cognitive function is impaired in elderly subjects. We did dental and medical examination in 85-years-old subjects in Fukuoka, Japan and studied the relationship between chewing ability and cognitive function. The role of arterial stiffness on cognitive function was also determined.
Methods and Results: This study was designed to explore the relationship between the systemic and dental health conditions of very elderly subjects. Chewing ability was expressed as a number of the selected foods which a subject could chew. Cognitive function and arterial stiffness were assessed by the mini-mental state examination (MMSE) and measurement of the brachial-ankle pulse wave velocity (PWV), respectively. Two-hundred and seven 85 years-old residents participated the survey and 205 (88 men and 117 women) completed the dental and physical examination, and MMSE. MMSE score was 23.8 ±0.3 (mean ± SE, full score 30) and the number of foods chewed was 10.7 ± 0.3 (full score 15). T … More here was a tendency towards positive correlation between the MMSE score and the number of foods chewed (coefficient of correlation 0.12, p=0.08). When we divided the subjects into 4 groups according to the chewing ability (the number of foods chewed 0-4, 5-9, 10-14, 15), the MMSE score of each group was 22.7 ± 1.3, 23.6 ± 0.7, 23.9 ± 0.5, 24.4 ± 0.5. We also studied the cross-sectional association of the MMSE score and PWV in 203 subjects (87 men and 116 women). Sex distribution, systolic and diastolic blood pressures did not differ between the normal (MMSE score 【greater than or equal】24, n=128) and impaired MMSE groups (MMSE score <24, n=75). In contrast, the PWV was significantly increased in the impaired MMSE group compared to the normal MMSE group (25.0 ± 0.8 vs. 22.9 ± 0.5 m/sec, p<0.05). In multiple regression analysis, the PWV was also independently and significantly associated with the MMSE score.
Conclusions: Oral care to keep chewing ability might prevent cognitive impairment. Cognitive function could be predicted by arterial stiffness as assessed by the PWV in very old subjects. Preventing atherosclerosis may play an important role in preserving normal cognitive function until very old age. Less

  • Research Products

    (28 results)

All 2007 2006 2005 2004

All Journal Article (28 results)

  • [Journal Article] Relationship between chewing ability and 4-year mortality in a cohort of 80-year-old Japanese people.2007

    • Author(s)
      Ansai T, Takata Y, Soh I, Akifusa S, Sogame A, Shimada N, Yoshida A, Hamasaki T, Awano S, Fukuhara M, Takehara T
    • Journal Title

      Oral Dis 13

      Pages: 214-219

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Hyperglycemia promotes microinflammation as evaluated by C-reactive protein in the very elderly.2007

    • Author(s)
      Fukuhara M, Matsumura K, Wakisaka M, Takata Y, Sonoki K, Fujisawa K, Ansai T, Akifusa S, Fujii K, Iida M, Takehara T
    • Journal Title

      Internal Medicine 46

      Pages: 207-212

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] High-level functional capacity and 4-year mortality in an 80-year-old population.2007

    • Author(s)
      Takata Y, Ansai T, Akifusa S, Soh I, Sonoki K, Takehara T
    • Journal Title

      Gerontology 53 (1)

      Pages: 365-368

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Relationship between chewing ability and 4-year mortality in a cohort of 80-year-old Japanese people.2007

    • Author(s)
      Ansai T, Takata Y, Soh I, Akifusa S, Sogame A, Shimada N, Yoshida A, Hamasaki T, Awano S, Fukuhara M, Takehara T.
    • Journal Title

      Oral Dis 13

      Pages: 214-219

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Hyperglycemia promotes microinflammation as evaluated by C-reactive protein in the very elderly.2007

    • Author(s)
      Fukuhara M, Matsumura K, Wakisaka M, Takata Y, Sonoki K, Fujisawa K, Ansai T, Akifusa S, Fujii K, Iida M, Takehara T.
    • Journal Title

      Internal Medicine 46

      Pages: 207-212

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] High-level functional capacity and 4-year mortality in an 80-year-old population.2007

    • Author(s)
      Takata Y, Ansai T, Akifusa S, Soh I, Sonoki K, Takehara T.
    • Journal Title

      Gerontology 53

      Pages: 365-368

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Prediction of Cognitive Function by Arterial Stiffness in the Very Elderly.2006

    • Author(s)
      Fukuhara M, Matsumura K, Ansai T, Takata Y, Sonoki K, Akifusa S, Wakisaka M, Hamasaki T, Fujisawa K, Yoshida A, Fujii K, Iida M, Takehara T
    • Journal Title

      Circulation J 70

      Pages: 756-761

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Prevalence of periodontopathic bacteria on the tongue dorsum of elderly people.2006

    • Author(s)
      Tachibana M, Yoshida A, Ansai T, Takata Y, Akifusa S, Fukuhara M, Takehara T
    • Journal Title

      Gerodontology 23

      Pages: 123-126

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Chewing and quality of life in an 80-year-old population.2006

    • Author(s)
      Takata Y, Ansai T, Awano S, Fukuhara M, Sonoki K, Wakisaka M, Fujisawa K, Takehara T
    • Journal Title

      J Oral Rehab 33

      Pages: 330-336

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Prediction of Cognitive Function by Arterial Stiffness in the Very Elderly.2006

    • Author(s)
      Fukuhara M, Matsumura K, Ansai T, Takata Y, Sonoki K, Akifusa S, Wakisaka M, Hamasaki T, Fujisawa K, Yoshida A, Fujii K, Iida M, Takehara T.
    • Journal Title

      Circulation J 70

      Pages: 756-761

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Prevalence of periodontopathic bacteria on the tongue dorsum of elderly people.2006

    • Author(s)
      Tachibana M, Yoshida A, Ansai T, Takata Y, Akifusa S, Fukuhara M, Takehara T.
    • Journal Title

      Gerodontology 23

      Pages: 123-126

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Chewing and quality of life in an 80-year-old population.2006

    • Author(s)
      Takata Y, Ansai T, Awano S, Fukuhara M, Sonoki K, Wakisaka M, Fujisawa K, Takehara T.
    • Journal Title

      J Oral Rehab 33

      Pages: 330-334

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Central and peripheral cardiovascular actions of apelin in conscious rats.2005

    • Author(s)
      Kagiyama S, Fukuhara M, Matsumura K, Lin Y, Fujii K, Iida M
    • Journal Title

      Regul Pept 125

      Pages: 55-59

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Relationship of number of remaining teeth to health-related quality of life in community-dwelling elderly.2005

    • Author(s)
      Akifusa S, Soh I, Ansai T, Hamasaki T, Takata Y, Yoshida A, Fukuhara M, Sonoki K, Takehara T
    • Journal Title

      Gerodontology 22

      Pages: 91-97

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Chronic administration of olmesartan attenuates the exaggerated pressor response to glutamate in the rostral ventrolateral medulla of SHR.2005

    • Author(s)
      Lin Y, Matsumura K, Kagiyama S, Fukuhara M, Fujii K, Iida M
    • Journal Title

      Brain Research 1058

      Pages: 161-166

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Tooth loss associated with abnormal electrocardiographic findings in octogenarians.2005

    • Author(s)
      Takata Y, Ansai T, Awano S, Sonoki K, Akifusa S, Fukuhara M, Wakisaka M, Takehara T
    • Journal Title

      J Kyushu Dent Soc 59

      Pages: 153-160

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Central and peripheral cardiovascular actions of apelin in conscious rats.2005

    • Author(s)
      Kagiyama S, Fukuhara M, Matsumura K, Lin Y, Fujii K, Iida M.
    • Journal Title

      Regul Pept 125

      Pages: 55-59

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Relationship of number of remaining teeth to health-related quality of life in community-dwelling elderly.2005

    • Author(s)
      Akifusa S, Soh I, Ansai T, Hamasaki T, Takata Y, Yoshida A, Fukuhara M, Sonoki K, Takehara T.
    • Journal Title

      Gerodontology 22

      Pages: 91-97

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Chronic administration of olmesartan attenuates the exaggerated pressor response to glutamate in the rostral ventrolateral medulla of SHR.2005

    • Author(s)
      Lin Y, Matsumura K, Kagiyama S, Fukuhara M, Fujii K, Iida M.
    • Journal Title

      Brain Research 1058

      Pages: 161-166

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Tooth loss associated with abnormal electrocardiographic findings in octogenarians.2005

    • Author(s)
      Takata Y, Ansai T, Awano S, Sonoki K, Akifusa S, Fukuhara M, Wakisaka M, Takehara T.
    • Journal Title

      J Kyushu Dent Soc 59

      Pages: 153-160

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Relationship of physical fitness to chewing in an 80-year-old population.2004

    • Author(s)
      Takata Y, Ansai T, Awano S, Hamasaki T, Yoshitake Y, Kimura Y, Sonoki K, Wakisaka M, Fukuhara M, Takehara T
    • Journal Title

      Oral Dis 10

      Pages: 44-49

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Ghrelin acts at the nucleus of the solitary tract to decrease arterial pressure in rats.2004

    • Author(s)
      Lin Y, Matsumura K, Fukuhara M, Kagiyama S, Fujii K, Iida M
    • Journal Title

      Hypertension 43

      Pages: 977-982

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Role of ERK and Rho kinase pathways in central pressor action of urotensin II.2004

    • Author(s)
      Lin Y, Matsumura K, Tsuchihashi T, Fukuhara M, Fujii K, Iida M
    • Journal Title

      J Hypertens 22

      Pages: 983-988

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Activities of daily living and chewing ability in an 80 year old population.2004

    • Author(s)
      Takata Y, Ansai T, Awano T, Sonoki K, Fukuhara M, Wakisaka M, Takehara T
    • Journal Title

      Oral Dis 10

      Pages: 365-368

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Relationship of physical fitness to chewing in an 80-year-old population.2004

    • Author(s)
      Takata Y, Ansai T, Awano S, Hamasaki T, Yoshitake Y, Kimura Y, Sonoki K, Wakisaka M, Fukuhara M, Takehara T.
    • Journal Title

      Oral Dis 10

      Pages: 44-49

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Ghrelin acts at the nucleus of the solitary tract to decrease arterial pressure in rats.2004

    • Author(s)
      Lin Y, Matsumura K, Fukuhara M, Kagiyama S, Fujii K, Iida M.
    • Journal Title

      Hypertension 43

      Pages: 977-982

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Role of ERK and Rho kinase pathways in central pressor action of urotensin II.2004

    • Author(s)
      Lin Y, Matsumura K, Tsuchihashi T, Fukuhara M, Fujii K, Iida M.
    • Journal Title

      J Hypertens 22

      Pages: 983-988

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Activities of daily living and chewing ability in an 80 year old population.2004

    • Author(s)
      Takata Y, Ansai T, Awano T, Sonoki K, Fukuhara M, Wakisaka M, Takehara T.
    • Journal Title

      Oral Dis 10

      Pages: 365-368

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2008-05-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi