• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2018 Fiscal Year Final Research Report

Methanol economy pioneered by C1-microorganisms: development of basic technologies utilized in low-carbon and sustainable society

Research Project

  • PDF
Project/Area Number 16H02997
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Design and evaluation of sustainable and environmental conscious system
Research InstitutionKyoto University

Principal Investigator

YURIMOTO Hiroya  京都大学, 農学研究科, 准教授 (00283648)

Research Collaborator SAKAI Yasuyoshi  
OKU Masahide  
Project Period (FY) 2016-04-01 – 2019-03-31
Keywords遺伝子発現制御 / 転写因子 / シグナル伝達 / 異種タンパク質生産 / メタノール / メタノール資化性酵母 / Methylobacterium
Outline of Final Research Achievements

C1-microorganisms that can utilize C1 compounds, such as methane and methanol, can be used for the bioprocess in the low carbon society “methanol economy”. In this project, we investigated molecular basis of C1-metabolism in C1-microorganisms and its application. We elucidated novel molecular functions of transcriptional regulators and signal transducers responsible for methanol-induced gene expression in methylotrophic yeasts which are used for heterologous protein production. Furthermore, we developed the basic technology of methanol production from biomass-derived sugar compounds and elucidated cellular functions relating to plant colonization of methylotrophic bacteria.

Free Research Field

応用微生物学

Academic Significance and Societal Importance of the Research Achievements

詳細な分子機構が不明であった強力なメタノール誘導性遺伝子発現の分子基盤およびメタノール応答性転写活性化機構に関して、メタノール感知に関わるセンサータンパク質を初めて同定するとともに、発現制御の新規な機構を明らかにすることができた。本研究で解明したC1微生物代謝生理機能の分子基盤や有用物質生産のための基盤技術は、持続可能システムとしての低炭素・循環型物質生産プロセスに活用することができる。

URL: 

Published: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi