Mother-infant interaction of functional flavonoids

2019 Fiscal Year Final Research Report

• Project/Area Number: 16H03040
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits
• Research Institution: University of Miyazaki
• Principal Investigator: Sakakibara Hiroyuki 宮崎大学, 農学部, 教授 (20403701)
• Co-Investigator(Kenkyū-buntansha): 芦田 均 神戸大学, 農学研究科, 教授 (90201889) ; 榊原 陽一 宮崎大学, 農学部, 教授 (90295197)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: 次世代伝承性 / フラボノイド / 機能性 / ケルセチン / アントシアニン / マウス

Outline of Final Research Achievements

In this project, we found that daily consumption of flavonoids increases their absorption rate, and also one of major functions is the effect of lipid metabolism. Therefore, we employed quercetin as candidate flavonoids, and evaluated it’s mother-infant interaction. Consequently, we obtained the following aspects: 1) hepatic triglyceride levels were significantly decreased in the infants from the mother consuming quercetin during the pregnancy, and this effect was remarkable in the groups consuming high-fat diet; 2) mice from mother consumed quercetin were sensitive for high-fat induced overweight comparing with mice from mother not consumed quercetin. In conclusion, our results clearly indicate the importance for mother-infant interaction of functions existed in dietary flavonoids.

Free Research Field

食品科学

Academic Significance and Societal Importance of the Research Achievements

本研究により，妊娠期間中の母体がフラボノイドを摂取すると，その生体調節機能が母体を介して次世代に伝わる可能性が示された。着目すべき点は，フラボノイドが有する抗肥満などの生体調節機能が，母体摂取により影響を受ける可能性が示唆されたことである。したがって，フラボノイドを豊富に含む野菜や果物，ないしはサプリメントを母体が摂取するときには，次世代へ伝わる作用を考慮に入れる必要があると考えた。