Importance of postexercise calcium ion dynamics to regulate the adaptation of myocytes

2019 Fiscal Year Final Research Report

• Project/Area Number: 16H03240
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sports science
• Research Institution: The University of Electro-Communications
• Principal Investigator: Kano Yutaka 電気通信大学, 大学院情報理工学研究科, 教授 (90293133)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: 骨格筋 / カルシウムイオン / 可塑性 / 性差 / 筋収縮 / 熱ストレス

Outline of Final Research Achievements

The mechanism of skeletal muscle adaptation to maintain muscle mass and strength is not fully understood. This study investigated the possibility that intracellular calcium ion controls muscle mass and muscle function. It was revealed that intracellular calcium ion changes continuously for a while after muscle contractions. These changes were different depending on the type of exercise stress and male/female. The characteristic calcium ion dynamics may control skeletal muscle mass due to exercise stress.

Free Research Field

運動生理学

Academic Significance and Societal Importance of the Research Achievements

加齢や寝たきりなどの不活動状態，あるいは代謝的疾患（糖尿病など）に関連した筋肉量の減少は，Quality of Life(QOL)や健康寿命などに直結するリスクファクターである．本研究によって解明された運動時のカルシウムイオン変動パターンは，筋肉量を維持するための運動トレーニングやリハビリテーションのプログラム開発への応用が期待される．