Establishment of clinical evidences for healthy life via integrated analysis of medical big data

2018 Fiscal Year Annual Research Report

• Project/Area Number: 16H03260
• Research Institution: Niigata University
• Principal Investigator: 曽根 博仁 新潟大学, 医歯学系, 教授 (30312846)
• Co-Investigator(Kenkyū-buntansha): 加藤 公則 新潟大学, 医歯学総合研究科, 特任教授 (00303165) ; 堀川 千嘉 新潟県立大学, 人間生活学部, 助教 (00734857) ; 赤澤 宏平 新潟大学, 医歯学総合病院, 教授 (10175771) ; 藤原 和哉 新潟大学, 医歯学総合研究科, 特任准教授 (10779341) ; 谷内 洋子 千葉県立保健医療大学, 健康科学部, 准教授 (30642821) ; 児玉 暁 新潟大学, 医歯学総合研究科, 特任准教授 (50638781) ; 齋藤 和美 茨城県立医療大学, 保健医療学部, 講師 (90467051)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 医療ビッグデータ / レセプト（診療報酬明細）データ / 特定健診 / 人間ドック / 検診 / 糖尿病 / 冠動脈疾患 / リスク因子

Outline of Annual Research Achievements

本年度は最終年度として、【プロジェクト２】「健康保険レセプト、検診・人間ドック、介護保険データの一体化による介護リスク因子の発見と予防策の確立」を中心に実施し、生活習慣調査も含む職域検診、特定健診、人間ドックと健康保険の診療報酬請求（レセプト）、介護保険などのデータベースを連結可能匿名化し、個人突合して解析することにより、糖尿病とその合併症、肥満、高血圧や動脈硬化疾患発症の発症リスクや病態を中心に、幅広い成果が得られ、前年、前々年と同様、診療、保健の現場に役立つ科学的エビデンスを多数樹立ことができた。研究成果は本年度のみで合計10本の英文原著論文にまとめた。
内容は多岐にわたるが一例を挙げると、2型糖尿病患者の多くは血糖、血圧、脂質など複数のリスク因子を抱え冠動脈疾患のリスクが高いことが知られているが、修正可能な血圧、LDL-C、HbA1c、喫煙習慣、4つのリスク因子全ての管理目標を達成した糖尿病群は、血圧、LDL-C、喫煙習慣のうち2つの管理目標を達成した非糖尿病群と比較し、冠動脈疾患リスクが上昇することはなかった。一方で、4つのリスク因子全ての管理目標を達成してない糖尿病群では、2つのリスク因子の管理目標を達成した非糖尿病群と比較し、CADリスクが9.4倍上昇していた。その他の成果としては、2型糖尿病患者が肥満しないために必要な、最低限度の運動量と最大限度の摂取エネルギーの組み合わせについての閾値もそれぞれ明らかにできた。
これらはいずれも、内外の臨床現場における、従来からのリサーチクエスチョンに対する回答となっており、これらの本研究の成果は、医師向けメディアなどで世界的に紹介され、世界の日常診療に貢献できた。

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Relationship between Number of Multiple Risk Factors and Coronary Artery Disease Risk With and Without Diabetes Mellitus (2019)
  • Author(s): Harada M, Fujihara K, Osawa T, Yamamoto M, Kaneko M, Kitazawa M, Matsubayashi Y, Yamada T, Yamanaka N, Seida H, Ogawa W, Sone H
  • Journal Title: J Clin Endocrinol Metab Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1210/jc.2019-00168
  • Peer Reviewed
• [Journal Article] Combined Effects of Energy Intake and Physical Activity on Obesity in Japanese Patients with Type 2 Diabetes (JDDM 50): A Cross-Sectional Study (2019)
  • Author(s): Hatta M, Fujihara K, Morikawa SY, Takeda Y, Ishii D, Horikawa C, Kato, M, Yokoyama H, Kurihara Y, Iwasaki K, Miyazawa K, Yamazaki K, Tanaka S, Maegawa H, Sone H
  • Journal Title: Diabetes Ther Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1007/s13300-019-0610-x.
  • Peer Reviewed / Open Access
• [Journal Article] Association between Helicobacter pylori infection, eradication and diabetes mellitus. (2019)
  • Author(s): Kato M, Toda A, Yamamoto-Honda R, Arase Y, Sone H
  • Journal Title: J Diabetes Investig Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1111/jdi.13011
  • Peer Reviewed / Open Access
• [Journal Article] Association of treatment-achieved HbA1c with incidence of coronary artery disease and severe eye disease in diabetes patients (2019)
  • Author(s): Harada M, Fujihara K, Osawa T, Yamamoto M, Kaneko M, Ishizawa M, Matsubayashi Y, Yamada T, Yamanaka N, Seida H, Kodama S, Ogawa W, Sone H
  • Journal Title: Diabetes Metab Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1016/j.diabet.2018.08.009
  • Peer Reviewed
• [Journal Article] Physical Fitness Tests and Type 2 Diabetes Among Japanese: A Longitudinal Study From the Niigata Wellness Study (2019)
  • Author(s): Momma H, Sawada S, Kato K, Gando Y, Kawakami R, Miyachi M, Nagatomi R, Tashiro M, Ishizawa M, Kodama S, Iwanaga M, Fujihara K, Sone H
  • Journal Title: J Epidemiol Volume: 29(4) Pages: 139-146
  • DOI: 10.2188/jea.JE20170280
  • Peer Reviewed / Open Access
• [Journal Article] Meat intake and incidence of cardiovascular disease in Japanese patients with type 2 diabetes: analysis of the Japan Diabetes Complications Study (JDCS) (2019)
  • Author(s): Horikawa C, Kamada C, Tanaka S, Tanaka S, Araki A, Ito H, Matsunaga S, Fujihara K, Yoshimura Y, Ohashi Y, Akanuma Y, Sone H, Japan Diabetes Complications Study Group
  • Journal Title: Eur J Nutr Volume: 58(1) Pages: 281-290
  • DOI: 10.1007/s00394-017-1592-y
  • Peer Reviewed
• [Journal Article] 糖尿病予防に対する身体活動のエビデンス (2019)
  • Author(s): 児玉曉、曽根博仁
  • Journal Title: 体育の科学 Volume: 印刷中 Pages: 印刷中
• [Journal Article] Relationship between intake of fruit separately from vegetables and triglycerides - A meta-analysis (2018)
  • Author(s): Kodama S, Horikawa C, Fujihara K, Ishii D, Hatta M, Takeda Y, Kitazawa M, Matsubayashi Y, Shimano H, Kato K, Tanaka S, Sone H
  • Journal Title: Clin Nutr ESPEN Volume: 27 Pages: 53-58
  • DOI: 10.1016/j.clnesp.2018.07.001
  • Peer Reviewed / Open Access
• [Journal Article] Cardiovascular Disease in Japanese Patients with Type 2 Diabetes (2018)
  • Author(s): Fujihara K, Sone H
  • Journal Title: Ann Vasc Dis Volume: 11(1) Pages: 2-14
  • Peer Reviewed
• [Journal Article] Role of fatty liver in the association between obesity and reduced hepatic insulin clearance (2018)
  • Author(s): Matsubayashi Y, Yoshida A, Suganami H, Ishiguro H, Yamamoto M, Fujihara K, Kodama S, Tanaka S, Kaku K, Sone H
  • Journal Title: Diabetes Metab Volume: 44(2) Pages: 135-142
  • DOI: 10.1016/j.diabet.2017.12.003
  • Peer Reviewed
• [Journal Article] Relationships among cardiorespiratory fitness, muscular fitness, and cardiometabolic risk factors in Japanese adolescents: Niigata screening for and preventing the development of non-communicable disease study-Agano (NICE EVIDENCE Study-Agano) 2 (2018)
  • Author(s): Morikawa SY, Fujihara K, Hatta M, Osawa T, Ishizawa M, Yamamoto M, Furukawa K, Ishiguro H, Matsunaga S, Ogawa Y, Shimano H, Sone H
  • Journal Title: Pediatr Diabetes Volume: 19(4) Pages: 593-602
  • DOI: 10.1111/pedi.12623
  • Peer Reviewed / Open Access
• [Journal Article] Predictors of the response of HbA1c and body weight after SGLT2 inhibition (2018)
  • Author(s): Abe T, Matsubayashi Y, Yoshida A, Suganami H, Nojima T, Osawa T, Ishizawa M, Yamamoto M, Fujihara K, Tanaka S, Kaku K, Sone H
  • Journal Title: Diabetes Metab Volume: 44(2) Pages: 172-174
  • DOI: 10.1016/j.diabet.2017.10.003
  • Peer Reviewed
• [Journal Article] 糖尿病：糖尿病診療ガイドライン (2018)
  • Author(s): 曽根博仁
  • Journal Title: Medical View Point Volume: 40(1) Pages: 6-6
• [Journal Article] 糖尿病の疫学 (2018)
  • Author(s): 山本正彦、曽根博仁
  • Journal Title: OCULISTA Volume: 68 Pages: 1-9
• [Journal Article] 糖尿病に対する療養指導 (2018)
  • Author(s): 古川和郎、曽根博仁
  • Journal Title: 月刊地域医学 Volume: 32(7) Pages: 563-568
• [Journal Article] 血糖の日内変動の血管合併症への影響 (2018)
  • Author(s): 山田貴穂、曽根博仁
  • Journal Title: 内分泌・糖尿病・代謝内科 Volume: 46(5) Pages: 316-322
• [Journal Article] 医療ビッグデータ解析に基づく糖尿病患者の食事と合併症との関連 (2018)
  • Author(s): 曽根博仁
  • Journal Title: 栄養Trends of Nutrition Volume: 3(2) Pages: 95-99
• [Journal Article] 療ビッグデータとしての臨床検査データの利活用―糖尿病を中心とした生活習慣病分野を例に (2018)
  • Author(s): 曽根博仁
  • Journal Title: 生物試料分析 Volume: 41(2) Pages: 73-78
• [Journal Article] 糖尿病患者における薬物処方の現状と多剤処方 (2018)
  • Author(s): 藤原和哉、曽根博仁
  • Journal Title: カレントテラピー Volume: 36(2) Pages: 163-168
• [Presentation] Effects of treatment-achieved HbA1c on incidence of micro-/macrovascular complications in patients with diabetes (2018)
  • Author(s): Harada M, Fujihara K, Osawa T, Yamamoto M, Kaneko M, Ishizawa M, Matsubayashi Y, Yamada T, Yamanaka N, Hiroyasu S, Kodama S, Sone H
  • Organizer: 54th Annual Meeting of the European Association for the Study of Diabetes
  • Int'l Joint Research
• [Presentation] Effect of number of achieved targets for risk factors on coronary artery disease (CAD) in those with and without diabetes (2018)
  • Author(s): Fujihara K, Harada M, Yamamoto M, Matsubayashi Y, Kaneko M, Osawa T, Yamada T, Kato K, Kodama S, Sone H
  • Organizer: 54th Annual Meeting of the European Association for the Study of Diabetes
  • Int'l Joint Research
• [Presentation] Higher pulse pressure predicts initiation of dialysis in Japanese patients with diabetes: analysis using a nationwide claim database (2018)
  • Author(s): Osawa T, Fujihara K, Yamamoto M, Harada M, Ishizawa M, Seida H, Yamanaka N, Matsubayashi Y, Matsunaga S, Yamada T, Sone H
  • Organizer: 54th Annual Meeting of the European Association for the Study of Diabetes
  • Int'l Joint Research
• [Presentation] Education for Family Members Is Effective for Improved Glycemic Control of Patients With Type 2 Rather than Type 1 Diabetes Mellitus - A Meta-analysis (2018)
  • Author(s): Kodama S, Fujihara K, Ishiguro H, Horikawa C, Yachi Y, Ishizawa M, Matsunaga S, Tanaka S, Kato K, Sone H
  • Organizer: 78th American Diabetes Association Scientific Sessions (ADA)
  • Int'l Joint Research
• [Presentation] Dietary Energy Density (DED) Is Significantly Associated with Obesity in Japanese Patients with Type 2 Diabetes Mellitus (T2DM) (2018)
  • Author(s): Takeda Y, Fujihara K, Morikawa YS, Horikawa C, Hatta M, Ishii D, Hirasawa R, Yachi Y, Sone H
  • Organizer: 78th American Diabetes Association Scientific Sessions (ADA)
  • Int'l Joint Research
• [Presentation] Impact of Carbohydrate Intake on Obesity in Japanese Patients with Type 2 Diabetes - An Analysis of the JDCP Registry (2018)
  • Author(s): Matsunaga S, Sone H, Tsukada K, Oshida Y, Sakaki S, Satoh J, Hayashino Y, Nishimura R, Tajima N
  • Organizer: 78th American Diabetes Association Scientific Sessions (ADA).
  • Int'l Joint Research
• [Presentation] Effects of Treatment-Achieved HbA1c on Incidence of Micro-/Macrovascular Complications in Patients with Diabetes Mellitus (2018)
  • Author(s): Harada M, Fujihara K, Osawa T, Yamamoto M, Kaneko M, Matsubayashi Y, Matsunaga S, Yamada T, Yamanaka N, Seida H, Kodama S, Sone H
  • Organizer: 78th American Diabetes Association Scientific Sessions (ADA).
  • Int'l Joint Research
• [Presentation] Effect of Number of Achieved Targets for Risk Factors on Coronary Artery Disease (CAD) in Those With and Without Diabetes Mellitus (DM). (2018)
  • Author(s): Fujihara K, Matsubayashi Y, Kitazawa M, Yamamoto M, Osawa T, Kaneko M, Yamanaka N, Seida H, Kato K, Kodama S, Sone H
  • Organizer: 78th American Diabetes Association Scientific Sessions (ADA).
  • Int'l Joint Research
• [Presentation] Incidence and Risk Factors for Amputation in Patients with Diabetes in Japan - Historical Cohort Study Using a Nationwide Claims Database (2018)
  • Author(s): Kaneko M, Fujihara K, Yamamoto M, Kitazawa M, Ishizawa M, Osawa T, Harada M, Matsubayashi Y, Yamada T, Sone H
  • Organizer: 78th American Diabetes Association Scientific Sessions (ADA)
  • Int'l Joint Research
• [Presentation] Impact of Prior Coronary Artery Disease (CAD) and Glucose Tolerance Status (GTS) on Incident CAD in Japanese Men (2018)
  • Author(s): Kitazawa M, Fujihara K, Harada M, Ishizawa M, Yamamoto M, Kaneko M, Osawa T, Yamada T, Matsubayashi Y, Sone H
  • Organizer: 78th American Diabetes Association Scientific Sessions (ADA)
  • Int'l Joint Research
• [Presentation] Higher Dietary Intake of Vitamin D Is Associated with Lower Incidence of Diabetic Nephropathy in Japanese Patients with Type 2 Diabetes (2018)
  • Author(s): Horikawa C, Aida R, Tanaka S, Tanaka S, Kamada C, Yoshimura Y, Araki A, Moriya T, Katayama S, Sone H
  • Organizer: 78th American Diabetes Association Scientific Sessions (ADA)
  • Int'l Joint Research
• [Presentation] Reduced Postprandial Hepatic Insulin Clearance via the DPP-4 Inhibitor Anagliptin Contributed to Improvement in Hyperglycemia in Patients with Type 2 Diabetes Mellitus (2018)
  • Author(s): Matsubayashi Y, Abe T, Muragishi S, Yoshida A, Suganami H, FurusawaK, Yamada T, Fujihara K, Tanaka S, Kaku K, Sone H
  • Organizer: 78th American Diabetes Association Scientific Sessions (ADA)
  • Int'l Joint Research
• [Presentation] Influence of SGLT2 inhibitor on resting heart rate (RHR) and factors related to its changes (2018)
  • Author(s): Matsubayashi Y, Nojima T, Yoshida A, Suganami H, Yamada T, Fujihara K, Tanaka S, Kaku K, Sone H
  • Organizer: 78th American Diabetes Association Scientific Sessions (ADA)
  • Int'l Joint Research
• [Presentation] Impact of Vitamin B6 Intake on the Risk of Diabetic Retinopathy - Analysis from Multicenter Prospective Study of Japanese Patients with Type 2 Diabetes (2018)
  • Author(s): Horikawa C, Aida R, Tanaka S, Yoshimura Y, Kawasaki R, Moriya T, Araki A, Sone H
  • Organizer: 78th American Diabetes Association Scientific Sessions (ADA)
  • Int'l Joint Research
• [Presentation] Genetically Reduced Chondroitin Sulfate Prevents the Progression of Diabetic Neuropathy (2018)
  • Author(s): Ishiguro H, Ushiki T, Kawasaki A, Cho K, Masuko M, Sango K, Igashashi M, Sone H
  • Organizer: 78th American Diabetes Association Scientific Sessions (ADA)
  • Int'l Joint Research
• [Presentation] Test Strip-Positive Proteinuria and Its Combination with Low eGFR Are Predictive of Treatment-Required Eye Diseases in Japanese Patients with Diabetes Me (2018)
  • Author(s): Yamamoto M, Fujihara K, Osawa T, Harada M, Ishizawa M, Ishiguro H, Suzuki H, Seida H, Yamanaka N, Matsubayashi Y, Sone H
  • Organizer: 78th American Diabetes Association Scientific Sessions (ADA)
  • Int'l Joint Research
• [Book] 糖尿病治療のニューパラダイム 第4巻. 糖尿病網膜症の管理～臨床疫学から～ (2019)
  • Author(s): 古川和郎、川崎良、山下英俊、曽根博仁
  • Total Pages: 295
  • Publisher: 医薬ジャーナル社
  • ISBN: 978-4-7532-2878-2
• [Book] 日本臨床増刊号 老年医学（下）. 高齢者の身体活動と生活習慣病 (2018)
  • Author(s): 北澤勝、藤原和哉、曽根博仁
  • Total Pages: 793
  • Publisher: 日本臨床社
  • ISBN: 0047-1852
• [Book] 内分泌代謝科専門医研修ガイド. 第13章4 糖尿病の疫学と主要な大規模臨床試験 (2018)
  • Author(s): 藤原和哉、曽根博仁
  • Total Pages: 792
  • Publisher: 診断と治療社
  • ISBN: 9784787822925
• [Book] プラクティスセレクション 今度こそできる！糖尿病運動療法 サイエンス＆プラクティス. 第Ⅰ部 サイエンス 2．疫学から見た糖尿病患者における身体活動の意義 (2018)
  • Author(s): 山田貴穂、曽根博仁
  • Total Pages: 156
  • Publisher: 医歯薬出版株式会社
  • ISBN: 978-4263236543
• [Book] The Encyclopedia of Cardiovascular Research and Medicine - Cardiovascular Disease Epidemiology and Preventive Cardiology. Cardiovascular Epidemiology and Preventive Cardiology (2018)
  • Author(s): Sone H
  • Total Pages: 2800
  • Publisher: Elsevier
  • ISBN: 978-0-12-805154-2
• [Remarks] 新潟大学血液・内分泌・代謝内科ホームページ
  • URL: https://www.med.niigata-u.ac.jp/emh/research.html