2019 Fiscal Year Final Research Report

Elucidation of pathophysiology of anorexia nervosa and creation of new paradigm: Control of body weight and behavioral characteristics by intestinal bacteria

Research Project

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Project/Area Number	16H05278
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	General internal medicine(including psychosomatic medicine)
Research Institution	Kyushu University
Principal Investigator	Sudo Nobuyuki 九州大学, 医学研究院, 教授 (60304812)
Co-Investigator(Kenkyū-buntansha)	服部正平早稲田大学, 理工学術院, 教授(任期付) (70175537) 三上克央東海大学, 医学部, 准教授 (90548504) 吉原一文九州大学, 医学研究院, 講師 (20444854) 高倉修九州大学, 大学病院, 助教 (40532859) 波夛伴和九州大学, 大学病院, 助教 (10535983) 古賀泰裕東海大学, 医学部, 教授 (60170221)
Project Period (FY)	2016-04-01 – 2019-03-31
Keywords	神経性やせ症 / 腸内細菌 / 次世代シークエンサー / 無菌マウス
Outline of Final Research Achievements	Anorexia nervosa (AN) results in gut dysbiosis, but whether the dysbiosis contributes to AN-specific pathologies such as poor weight gain and neuropsychiatric abnormalities remains unclear. To address this, germ-free mice were reconstituted with the microbiota of AN restricting-type patients (gAN mice) and healthy control individuals (gHC mice). Compared with gHC mice, gAN mice showed a decrease in body weight gain, concomitant with reduced food intake. Both anxiety-related behavior measured by open-field tests and compulsive behavior measured by marble-burying test were increased only in gAN mice but not in gHC mice. Collectively, these results indicate that AN-specific dysbiosis may contribute to both poor weight gain and mental disorders in AN patients.
Free Research Field	心身医学
Academic Significance and Societal Importance of the Research Achievements	神経性やせ症患者における体重増加不良や不安、抑うつなどの精神症状の発現には、腸内細菌の異常が関与している可能性が示された。有効な治療法が限られている摂食障害においてプロバイオティクスやプレバイオティクスの有効性を示唆するものであり、神経性やせ症の病因論に立脚した新しい診断・治療の確立につながり得る。