A study to elucidate the mechanism by which sterile chronic inflammation occurs in arterial wall and perivascular adipose tissue

2018 Fiscal Year Annual Research Report

• Project/Area Number: 16H05299
• Research Institution: The University of Tokushima
• Principal Investigator: 佐田 政隆 徳島大学, 大学院医歯薬学研究部(医学域), 教授 (80345214)
• Co-Investigator(Kenkyū-buntansha): 福田 大受 徳島大学, 大学院医歯薬学研究部(医学域), 特任講師 (40637568) ; 添木 武 徳島大学, 大学院医歯薬学研究部(医学域), 准教授 (60393211)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 動脈硬化 / 慢性炎症 / 脂肪 / 自然免疫

Outline of Annual Research Achievements

動脈硬化巣内の細胞がアポトーシスやピロトーシス、ネクローシスといった細胞死を起こしており、動脈硬化の進展に関与していることが示唆された。また、肥満で大型化した脂肪細胞に細胞死が生じており、cell free DNA (cfDNA)といった遊離核酸断片を放出して、マクロファージを脂肪組織へリクルートして活性化していた。
そこで、刺激を受けたり、細胞死に至った脂肪細胞から放出されたcfDNAがマクロファージを活性化する機序を検討した。3T3L1脂肪細胞を低酸素、過酸化水素、TNFα、Angiotensin IIなどを用いて細胞死を誘導して、培養上清を採取した。また、培養上清を野生型もしくはTLR9欠損マウス由来マクロファージに添加して、活性化状態をNFκBやサイトカインの発現で検討した。3T3L1脂肪細胞培養上清中のDNAを濃縮して、野生型ならびにTLR9欠損マウス由来のマクロファージに添加した。野生型ではMCP-1の産生が亢進し、脂肪細胞をTNF-αで傷害しておくとその程度が増強した。脂肪細胞培養上清によるマクロファージ活性化作用は、TLR9欠損マウス由来のマクロファージでは減弱していた。また、TLR9 に対してのinhibitory オリゴヌクレオチドを投与すると野生型における活性化がブロックされた。
今回、我々の研究によって、生活習慣病によって、脂肪細胞や血管細胞の細胞死を引き起こし、そこから放出されるDNAが自然免疫受容体TLR9を活性化し、慢性炎症を惹起することが明らかとなった。生活習慣病によって生じるインスリン抵抗性、動脈硬化を防ぐうえで、自己DNA/TLR9 系がキーとなる経路であることが明らかとなった。今後、自己DNA/TLR9 系を標的として、新たな生活習慣病の合併症治療法の開発が行われることが期待される。

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Efficacy and safety of alirocumab 150 mg every 4 weeks in hypercholesterolemic patients on non-statin lipid-lowering therapy or lowest strength dose of statin: ODYSSEY NIPPON (2019)
  • Author(s): Teramoto Tamio、Kiyosue Arihiro、Ishigaki Yasushi、Harada-Shiba Mariko、Kawabata Yumiko、Ozaki Asuka、Baccara-Dinet Marie T.、Sata Masataka
  • Journal Title: Journal of Cardiology Volume: 73 Pages: 218～227
  • DOI: 10.1016/j.jjcc.2018.10.004
  • Peer Reviewed
• [Journal Article] Recurrent venous thromboembolism after discontinuation of rivaroxaban therapy in a patient with antiphospholipid syndrome (2019)
  • Author(s): Yagi Shusuke、Nishiyama Seiichi、Abe Toshio、Sata Masataka
  • Journal Title: BMJ Case Reports Volume: 12 Pages: bcr～2018-227663
  • DOI: doi: 10.1136/bcr-2018-227663
  • Peer Reviewed
• [Journal Article] Toll‐Like Receptor 9 Plays a Pivotal Role in Angiotensin II?Induced Atherosclerosis (2019)
  • Author(s): Fukuda Daiju、Nishimoto Sachiko、Kim‐Kaneyama Joo‐ri、Lei Xiao‐Feng、Masuda Kiyoshi、Naruto Takuya、Tanaka Kimie、Higashikuni Yasutomi、Hirata Yoichiro、Yagi Shusuke、Kusunose Kenya、Yamada Hirotsugu、Soeki Takeshi、Imoto Issei、Akasaka Takashi、Shimabukuro Michio、Sata Masataka
  • Journal Title: Journal of the American Heart Association Volume: 8 Pages: e010860
  • DOI: doi: 10.1161/JAHA.118.010860
  • Peer Reviewed / Open Access
• [Journal Article] Association of Decreased Docosahexaenoic Acid Level After Statin Therapy and Low Eicosapentaenoic Acid Level with In-Stent Restenosis in Patients with Acute Coronary Syndrome (2019)
  • Author(s): Yagi Shusuke、Kondo Daisuke、Yamaguchi Koji、Wakatsuki Tetsuzo、Kawabata Yutaka、Ito Hiroyuki、Saijo Yoshihito、Seno Hiromitsu、Sutou Kumiko、Ueno Rie、Todoroki Takafumi、Kusunose Kenya、Matsuura Tomomi、Tobiume Takeshi、Yamada Hirotsugu、Soeki Takeshi、Shimabukuro Michio、Aihara Ken-ichi、Akaike Masashi、Sata Masataka
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 26 Pages: 272～281
  • DOI: doi: 10.5551/jat.44735
  • Peer Reviewed
• [Journal Article] Sequential speckle tracking imaging to detect early stage of cancer therapeutics-related cardiac dysfunction in a patient with breast cancer (2019)
  • Author(s): Saijo Yoshihito、Kusunose Kenya、Yamada Nao、Yamada Hirotsugu、Nishio Susumu、Hirata Yukina、Sata Masataka
  • Journal Title: Journal of Echocardiography Volume: 印刷中 Pages: 印刷中
  • DOI: doi: 10.1007/s12574-019-00423-2
  • Peer Reviewed
• [Journal Article] Noninvasive assessment of left-ventricular diastolic electromechanical coupling in hypertensive heart disease (2019)
  • Author(s): Saito Yuko、Yamada Hirotsugu、Kusunose Kenya、Saito Ken、Sata Masataka
  • Journal Title: Journal of Echocardiography Volume: 印刷中 Pages: 印刷中
  • DOI: doi: 10.1007/s12574-019-00421-4
  • Peer Reviewed
• [Journal Article] Target of Triglycerides as Residual Risk for Cardiovascular Events in Patients With Coronary Artery Disease ― Post Hoc Analysis of the FMD-J Study A ― (2019)
  • Author(s): Kajikawa Masato、Noma Kensuke、Nakashima Ayumu、Tomiyama Hirofumi、Takase Bonpei、Kohro Takahide、Suzuki Toru、Ishizu Tomoko、Ueda Shinichiro、Yamazaki Tsutomu、Furumoto Tomoo、Kario Kazuomi、Inoue Teruo、Koba Shinji、Watanabe Kentaro、Takemoto Yasuhiko、Hano Takuzo、Sata Masataka et al.
  • Journal Title: Circulation Journal Volume: 印刷中 Pages: 印刷中
  • DOI: doi: 10.1253/circj.CJ-18-1082
  • Peer Reviewed / Open Access
• [Journal Article] Local Thickness of Epicardial Adipose Tissue Surrounding the Left Anterior Descending Artery Is a Simple Predictor of Coronary Artery Disease ― New Prediction Model in Combination With Framingham Risk Score ― (2018)
  • Author(s): Maimaituxun Gulinu、Shimabukuro Michio、Fukuda Daiju、Yagi Shusuke、Hirata Yukina、Iwase Takashi、Takao Shoichiro、Matsuura Tomomi、Ise Takayuki、Kusunose Kenya、Tobiume Takeshi、Yamaguchi Koji、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Harada Masafumi、Sata Masataka
  • Journal Title: Circulation Journal Volume: 82 Pages: 1369～1378
  • DOI: doi: 10.1253/circj.CJ-17-1289
  • Peer Reviewed / Open Access
• [Journal Article] Minimal Shortening of Leukocyte Telomere Length Across Age Groups in a Cross-Sectional Study for Carriers of a Longevity-Associated FOXO3 Allele (2018)
  • Author(s): Davy Philip M C、Willcox D Craig、Shimabukuro Michio、Donlon Timothy A、Torigoe Trevor、Suzuki Makoto、Higa Moritake、Masuzaki Hiroaki、Sata Masataka、Chen Randi、Murkofsky Rachel L、Morris Brian J、Lim Eunjung、Allsopp Richard C、Willcox Bradley J
  • Journal Title: The Journals of Gerontology: Series A Volume: 73 Pages: 1448～1452
  • DOI: https://doi.org/10.1093/gerona/gly071
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Protease-Activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in Apolipoprotein E?Deficient Mice (2018)
  • Author(s): Hara Tomoya、Phuong Pham Tran、Fukuda Daiju、Yamaguchi Koji、Murata Chie、Nishimoto Sachiko、Yagi Shusuke、Kusunose Kenya、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Imoto Issei、Shimabukuro Michio、Sata Masataka
  • Journal Title: Circulation Volume: 138 Pages: 1706～1719
  • DOI: 10.1161/CIRCULATIONAHA.118.033544
  • Peer Reviewed
• [Journal Article] Prognostic Value of Frailty and Diastolic Dysfunction in Elderly Patients (2018)
  • Author(s): Kusunose Kenya、Okushi Yuichiro、Yamada Hirotsugu、Nishio Susumu、Torii Yuta、Hirata Yukina、Saijo Yoshihito、Ise Takayuki、Yamaguchi Koji、Yagi Shusuke、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka
  • Journal Title: Circulation Journal Volume: 82 Pages: 2103～2110
  • DOI: https://doi.org/10.1253/circj.CJ-18-0017
  • Peer Reviewed / Open Access
• [Journal Article] Effect of the Epicardial Adipose Tissue Volume on the Prevalence of Paroxysmal and Persistent Atrial Fibrillation (2018)
  • Author(s): Oba Kageyuki、Maeda Minetaka、Maimaituxun Gulinu、Yamaguchi Satoshi、Arasaki Osamu、Fukuda Daiju、Yagi Shusuke、Hirata Yukina、Nishio Susumu、Iwase Takashi、Takao Shoichiro、Kusunose Kenya、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Harada Masafumi、Masuzaki Hiroaki、Sata Masataka、Shimabukuro Michio
  • Journal Title: Circulation Journal Volume: 82 Pages: 1778～1787
  • DOI: https://doi.org/10.1253/circj.CJ-18-0021
  • Peer Reviewed / Open Access
• [Journal Article] Clinical, Electrocardiographic, and Echocardiographic Parameter Combination Predicts the Onset of Atrial Fibrillation (2018)
  • Author(s): Soeki Takeshi、Matsuura Tomomi、Tobiume Takeshi、Bando Sachiko、Matsumoto Kazuhisa、Nagano Hiromi、Uematsu Etsuko、Kusunose Kenya、Ise Takayuki、Yamaguchi Koji、Yagi Shusuke、Fukuda Daiju、Yamada Hirotsugu、Wakatsuki Tetsuzo、Shimabukuro Michio、Sata Masataka
  • Journal Title: Circulation Journal Volume: 82 Pages: 2253～2258
  • DOI: https://doi.org/10.1253/circj.CJ-17-0758
  • Peer Reviewed / Open Access
• [Journal Article] Cross-sectional and longitudinal associations between serum uric acid and endothelial function in subjects with treated hypertension (2018)
  • Author(s): Tanaka Atsushi、Tomiyama Hirofumi、Ishizu Tomoko、Higashi Yukihito、Takase Bonpei、Ueda Shinichiro、Furumoto Tomoo、Kario Kazuomi、Inoue Teruo、Koba Shinji、Takemoto Yasuhiko、Hano Takuzo、Sata Masataka、Ishibashi Yutaka、Maemura Koji、Ohya Yusuke、Furukawa Taiji、Ito Hiroshi、Yamashina Akira、Node Koichi
  • Journal Title: International Journal of Cardiology Volume: 272 Pages: 308～313
  • DOI: 10.1016/j.ijcard.2018.06.017
  • Peer Reviewed
• [Journal Article] Ticagrelor, a P2Y12 antagonist, attenuates vascular dysfunction and inhibits atherogenesis in apolipoprotein-E-deficient mice (2018)
  • Author(s): Ganbaatar Byambasuren、Fukuda Daiju、Salim Hotimah Masdan、Nishimoto Sachiko、Tanaka Kimie、Higashikuni Yasutomi、Hirata Yoichiro、Yagi Shusuke、Soeki Takeshi、Sata Masataka
  • Journal Title: Atherosclerosis Volume: 275 Pages: 124～132
  • DOI: doi: 10.1016/j.atherosclerosis.2018.05.053
  • Peer Reviewed
• [Journal Article] A clinical application of preload stress echocardiography for predicting future hemodynamic worsening in patients with early-stage heart failure (2018)
  • Author(s): Saijo Yoshihito、Yamada Hirotsugu、Kusunose Kenya、Bando Mika、Nishio Susumu、Torii Yuta、Hirata Yukina、Seno Hiromitsu、Matsuura Tomomi、Ise Takayuki、Tobiume Takeshi、Yamaguchi Koji、Yagi Shusuke、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka
  • Journal Title: Echocardiography Volume: 35 Pages: 1587～1595
  • DOI: doi: 10.1111/echo.14098
  • Peer Reviewed
• [Journal Article] Endothelial Dysfunction, Increased Arterial Stiffness, and Cardiovascular Risk Prediction in Patients With Coronary Artery Disease: FMD‐J (Flow‐Mediated Dilation Japan) Study A (2018)
  • Author(s): Maruhashi Tatsuya、Nakashima Ayumu、Goto Chikara、Tomiyama Hirofumi、Takase Bonpei、Kohro Takahide、Suzuki Toru、Ishizu Tomoko、Ueda Shinichiro、Yamazaki Tsutomu、Furumoto Tomoo、Kario Kazuomi、Inoue Teruo、Koba Shinji、Watanabe Kentaro、Takemoto Yasuhiko、Hano Takuzo、Sata Masataka et al.
  • Journal Title: Journal of the American Heart Association Volume: 7 Pages: e008588
  • DOI: 10.1161/JAHA.118.008588
  • Peer Reviewed / Open Access
• [Journal Article] Right Ventricular Function and Beneficial Effects of Cardiac Rehabilitation in Patients With Systolic Chronic Heart Failure (2018)
  • Author(s): Kusunose Kenya、Seno Hiromitsu、Yamada Hirotsugu、Nishio Susumu、Torii Yuta、Hirata Yukina、Saijo Yoshihito、Ise Takayuki、Yamaguchi Koji、Fukuda Daiju、Yagi Shusuke、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka
  • Journal Title: Canadian Journal of Cardiology Volume: 34 Pages: 1307～1315
  • DOI: 10.1016/j.cjca.2018.06.003
  • Peer Reviewed
• [Journal Article] Epicardial Fat and Pericardial Fat Surrounding the Heart Have Different Characteristics (2018)
  • Author(s): Hirata Yukina、Yamada Hirotsugu、Sata Masataka
  • Journal Title: Circulation Journal Volume: 82 Pages: 2475～2476
  • DOI: https://doi.org/10.1253/circj.CJ-18-0923
  • Peer Reviewed / Open Access
• [Journal Article] Usefulness of Epicardial Adipose Tissue Volume to Predict Recurrent Atrial Fibrillation After Radiofrequency Catheter Ablation (2018)
  • Author(s): Maeda Minetaka、Oba Kageyuki、Yamaguchi Satoshi、Arasaki Osamu、Sata Masataka、Masuzaki Hiroaki、Shimabukuro Michio
  • Journal Title: The American Journal of Cardiology Volume: 122 Pages: 1694～1700
  • DOI: 10.1016/j.amjcard.2018.08.005
  • Peer Reviewed
• [Journal Article] Possible Roles of Epicardial Adipose Tissue in the Pathogenesis of Coronary Atherosclerosis (2018)
  • Author(s): Tanaka Kimie、Sata Masataka
  • Journal Title: Annals of Nuclear Cardiology Volume: 4 Pages: 5～10
  • DOI: https://doi.org/10.17996/anc.18-00079
  • Peer Reviewed
• [Journal Article] Activation of Toll-Like Receptor 9 Impairs Blood Flow Recovery After Hind-Limb Ischemia (2018)
  • Author(s): Nishimoto Sachiko、Aini Kunduziayi、Fukuda Daiju、Higashikuni Yasutomi、Tanaka Kimie、Hirata Yoichiro、Yagi Shusuke、Kusunose Kenya、Yamada Hirotsugu、Soeki Takeshi、Shimabukuro Michio、Sata Masataka
  • Journal Title: Frontiers in Cardiovascular Medicine Volume: 5 Pages: 144
  • DOI: 10.3389/fcvm.2018.00144
  • Peer Reviewed / Open Access
• [Journal Article] Distinct Incidence of Takotsubo Syndrome Between Amyotrophic Lateral Sclerosis and Synucleinopathies: A Cohort Study (2018)
  • Author(s): Izumi Yuishin、Miyamoto Ryosuke、Fujita Koji、Yamamoto Yuki、Yamada Hirotsugu、Matsubara Tomoyasu、Unai Yuki、Tsukamoto Ai、Takamatsu Naoko、Nodera Hiroyuki、Hayashi Shinya、Oda Masaya、Mori Atsuko、Nishida Yoshihiko、Watanabe Shunsuke、Ogawa Hirohisa、Uehara Hisanori、Murayama Shigeo、Sata Masataka、Kaji Ryuji
  • Journal Title: Frontiers in Neurology Volume: 9 Pages: 1099
  • DOI: 10.3389/fneur.2018.01099
  • Peer Reviewed / Open Access
• [Journal Article] Left atrial functional response after a marathon in healthy amateur volunteers (2018)
  • Author(s): Hirata Yukina、Kusunose Kenya、Yamada Hirotsugu、Morita Sae、Torii Yuta、Nishio Susumu、Zheng Robert、Saijo Yoshihito、Fukuda Daiju、Yagi Shusuke、Soeki Takeshi、Sata Masataka
  • Journal Title: The International Journal of Cardiovascular Imaging Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1007/s10554-018-1502-2
  • Peer Reviewed
• [Journal Article] Simultaneous Pulmonary Arterial and Venous Round Structures in Pulmonary Aspergillosis (2018)
  • Author(s): Yagi Shusuke、Yamazaki Hiromu、Nishio Susumu、Kusunose Kenya、Yamada Hirotsugu、Sata Masataka
  • Journal Title: Circulation Journal Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1253/circj.CJ-18-0898
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of Atherosclerotic Plaque Development by Oral Administration of α-Glucosyl Hesperidin and Water-Dispersible Hesperetin in Apolipoprotein E Knockout Mice (2018)
  • Author(s): Sugasawa Noriko、Katagi Ayako、Kurobe Hirotsugu、Nakayama Taisuke、Nishio Chika、Takumi Hiroko、Higashiguchi Fumiharu、Aihara Ken-ichi、Shimabukuro Michio、Sata Masataka、Kitagawa Tetsuya
  • Journal Title: Journal of the American College of Nutrition Volume: 38 Pages: 15～22
  • DOI: 10.1080/07315724.2018.1468831
  • Peer Reviewed
• [Presentation] Gender disparities of distribution of epicardial adipose tissue and its impact on coronary artery disease (2018)
  • Author(s): Gulinu Maimaituxun, Shimabukuro M, Fukuda D, Yagi S, Hirata Y, Iwase T, Matsuura T, Ise T , Kusunose K, Tobiume T, Yamaguchi K, Yamada H, Soeki T, Wakatsuki T, Sata M.
  • Organizer: ESC2018,Munich,August 25-28,2018
  • Int'l Joint Research
• [Presentation] Localization of myocardial injury in anthracycline-induced cardiotoxicity: evaluation using two-dimensional speckle tracking echocardiography (2018)
  • Author(s): Saijo Y, Kusunose K, Bando M, Seno H, Zheng R, Nishio S, Hirata Y, Tori Y, Amano R, Yamada H, Sata M
  • Organizer: ESC2018,Munich,August 25-28,2018
  • Int'l Joint Research
• [Presentation] Atheroprotective effects of ticagrelor, a P2Y12 antagonist, in apolipoprotein-E-deficient mice (2018)
  • Author(s): Byambasuren Ganbaatar, Fukuda D, Salim HM, Yagi S, Soeki T, Sata M
  • Organizer: ESC2018,Munich,August 25-28,2018
  • Int'l Joint Research
• [Presentation] Growth of vasa vasorum is associated with local inflammation around coronary plaque in fresh cadavers (2018)
  • Author(s): Ito H, Wakatsuki T, Yamaguchi K, Fukuda D, Kawabata Y, Todoroki T, Matsuura T, Ise T, Kusunose K, Tobiume T, Yagi S, Yamada H, Soeki T, Sata M
  • Organizer: ESC2018,Munich,August 25-28,2018
  • Int'l Joint Research
• [Presentation] C-type natriuretic peptide improves left ventricular diastolic dysfunction and ischemia/reperfusion injury-associated ventricular arrhythmias. (2018)
  • Author(s): Soeki T, Uematsu E, Matsuura T, Tobiume T, Kusunose K, Ise T, Yamaguchi K, Yagi S, Fukuda D, Yamada H, Wakatsuki T, Sata M
  • Organizer: ESC2018,Munich,August 25-28,2018 6.
  • Int'l Joint Research
• [Presentation] Inhibition of S1P2 receptor ameliorates endothelial dysfunction and prevents atherogenesis in apolipoprotein-E-deficient Mice. (2018)
  • Author(s): Byambasuren Ganbaatar, Fukuda D, Yagi S, Soeki T, Sata M.
  • Organizer: ESC2018,Munich,August 25-28,2018
  • Int'l Joint Research
• [Presentation] Role of epicardial fat in cardiovascular disease (2018)
  • Author(s): Sata M
  • Organizer: ESC2018,Munich,August 25-28,2018
  • Int'l Joint Research / Invited
• [Presentation] Epicardial Adipose Tissue Thickness Measured by Echocardiography is Useful Marker for Predicting Coronary Artery Disease (2018)
  • Author(s): Hirata Y, Kusunose K, Yamada H, Nishio S, Harada O, Miyazato N, Haraguni A, Ito A, Yamaguchi K, Soeki T, Wakatsuki T, Sata M.
  • Organizer: AHA 2018, Chicago, November 10-12,2018
  • Int'l Joint Research
• [Presentation] A Deep Learning Approach for Automated Diagnosis of Regional Wall Motion Abnormality on Echocardiography (2018)
  • Author(s): Kusunose K, Abe T, Haga A, Yamada H, Fukuda D, Harada M, Sata M
  • Organizer: AHA 2018, Chicago, November 10-12,2018
  • Int'l Joint Research
• [Presentation] Right Ventricular Contractile Function Predicts Cardiac Events in Passive and Reactive Pulmonary Hypertension. (2018)
  • Author(s): Saijo Y, Kusunose K, Yamada H, Nishio S, Torii Y, Hirata Y, Ise T, Yamaguchi K, Yagi S, Soeki T,Wakatsuki T,Sata M
  • Organizer: AHA 2018, Chicago, November 10-12,2018
  • Int'l Joint Research
• [Presentation] Inhibition of Thrombin-PARs Signaling by Dabigatran, a Direct Thrombin Inhibitor, Attenuates Endothelial Dysfunction in Diabetic Mice (2018)
  • Author(s): Fukuda D, Yagi S, Kusunose K, Yamada H, Soeki T, Sata M.
  • Organizer: AHA 2018, Chicago, November 10-12,2018
  • Int'l Joint Research
• [Presentation] Rivaroxaban, a Direct Inhibitor of Factor Xa, Attenuates Endothelial Dysfunction in Streptozotocin-Induced Diabetic Mice Through the Inhibition of Protease-Activated Receptor 2 Signaling (2018)
  • Author(s): ham Tran Phuong, Fukuda D, Yagi S, Kusunose K,Yamada H, Soeki T, Shimabukuro M, Sata M
  • Organizer: AHA 2018, Chicago, November 10-12,2018
  • Int'l Joint Research