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2016 Fiscal Year Annual Research Report

A Scalable Time-Domain Sensor Integrated Circuit for High-Resolution Bioimaging

Research Project

Project/Area Number 16H06088
Research InstitutionNagoya University

Principal Investigator

新津 葵一  名古屋大学, 工学研究科, 講師 (40584785)

Project Period (FY) 2016-04-01 – 2020-03-31
Keywords電子デバイス・機器 / バイオイメージング / 集積回路 / バイオデバイス / デバイス設計・製造プロセス / IoT / ヘルスケア / スマートセンサ
Outline of Annual Research Achievements

本年度の研究においては、半導体集積回路製造プロセスの微細化に伴って空間・数値解像度向上が可能(スケーラブル)なバイオセンサ集積回路を実現するための手法の提案ならびに実デバイス上での実証を行った。半導体集積回路製造プロセスを用いたバイオセンサ集積回路の空間・数値解像度向上を実現することで、生命科学の発展や医療技術の向上への貢献が見込まれる。
スケーラブルなバイオセンサ集積回路のアーキテクチャとしてログドメインの時間デジタル変換回路技術の着想に至った。世界で初めて時間増幅率が1以下の時間差増幅回路(すなわち、時間差減衰回路)を提案して、その時間差減衰回路を繰り返し使用してログドメインを実現するサイクリック・時間減衰型ログドメイン時間分解能バイオセンサ集積回路アーキテクチャを実現した。
バイオセンシングにおける基本となる化学反応式であるネルンストの式はログドメインであるため、バイオセンシングに最適な時間分解能型回路技術の開発に成功した。デジタル回路ベースでの実装が可能であるため、集積回路の微細化との親和性が高く、まさにスケーラビリティに優れた回路方式である。
計算機上の回路シミュレーションで性能を確認するとともに、実際の半導体集積回路製造プロセスで実デバイス集積回路の試作を行い、評価を行った。半導体集積回路製造プロセスについては、社会実装を見据えて広く普及している半導体集積回路製造プロセスを選定した。回路シミュレーションでの検証後にマスクレイアウトまでを自ら実施した。評価を行ったところ、期待通りのログドメインでの出力が確認できた。回路シミュレーションとおおむね一致した評価結果が得られた。

Current Status of Research Progress
Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

当初は計画していなかったログドメインの時間デジタル変換回路の回路アーキテクチャに着想し、その性能を確認・実証できたため。

Strategy for Future Research Activity

さらに研究開発を加速するべく、新たな回路方式についての検討を行っていく。

  • Research Products

    (23 results)

All 2017 2016 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (14 results) (of which Int'l Joint Research: 12 results,  Invited: 2 results) Remarks (3 results)

  • [Journal Article] Well-Shaped Microelectrode Array Structure for High-Density CMOS Amperometric Electrochemical Sensor Array2016

    • Author(s)
      Kiichi Niitsu, Tsuyoshi Kuno, Masayuki Takihi, and Kazuo Nakazato
    • Journal Title

      IEICE Transactions on Electronics

      Volume: E99-C Pages: 663-666

    • DOI

      10.1587/transele.E99.C.663

    • Peer Reviewed
  • [Journal Article] Design, theoretical analysis, and experimental verification of a CMOS current integrator with 1.2 × 2.05 μm2microelectrode array for high-sensitivity bacterial counting2016

    • Author(s)
      Kohei Gamo, Kazuo Nakazato, and Kiichi Niitsu
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56 Pages: 01AH01~01AH01

    • DOI

      10.7567/JJAP.56.01AH01

    • Peer Reviewed
  • [Journal Article] Energy-efficient and low-voltage design methodology for a supply-sensing CMOS biosensor using biofuel cells for energy-autonomous healthcare applications2016

    • Author(s)
      Atsuki Kobayashi, Kei Ikeda, Kazuo Nakazato, and Kiichi Niitsu
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56 Pages: 01AH03~01AH03

    • DOI

      10.7567/JJAP.56.01AH03

    • Peer Reviewed
  • [Journal Article] Enhancement in open-circuit voltage of implantable CMOS-compatible glucose fuel cell by improving the anodic catalyst2016

    • Author(s)
      Kiichi Niitsu, Takashi Ando, Atsuki Kobayashi, and Kazuo Nakazato
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56 Pages: 01AH04~01AH04

    • DOI

      10.7567/JJAP.56.01AH04

    • Peer Reviewed
  • [Journal Article] Design and experimental verification of CMOS magnetic-based microbead detection using an asynchronous intra-chip inductive-coupling transceiver2016

    • Author(s)
      Kiichi Niitsu, Atsuki Kobayashi, Kohei Yoshida, and Kazuo Nakazato
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56 Pages: 01AH05~01AH05

    • DOI

      10.7567/JJAP.56.01AH05

    • Peer Reviewed
  • [Journal Article] Design, experimental verification, and analysis of a 1.8-V-input-range voltage-to-current converter using source degeneration for low-noise multimodal CMOS biosensor array2016

    • Author(s)
      Kiichi Niitsu, Kei Ikeda, Keita Muto, and Kazuo Nakazato
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56 Pages: 01AH06~01AH06

    • DOI

      10.7567/JJAP.56.01AH06

    • Peer Reviewed
  • [Presentation] A Current-Integration-Based CMOS Amperometric Sensor with 1.2 μm × 2.05 μm Electroless-Plated Microelectrode Array for High-Sensitivity Bacteria Counting2017

    • Author(s)
      Kohei Gamo, Kazuo Nakazato, and Kiichi Niitsu
    • Organizer
      ACM/IEEE Asia and South Pacific Design Automation Conference (ASP-DAC 2017)
    • Int'l Joint Research
  • [Presentation] A Scalable Time-Domain Biosensor Array Using Logarithmic Cyclic Time-Attenuation-Based TDC for High-Resolution and Large-Scale Bio-Imaging2017

    • Author(s)
      Kei Ikeda, Atsuki Kobayashi, Kazuo Nakazato, and Kiichi Niitsu
    • Organizer
      ACM/IEEE Asia and South Pacific Design Automation Conference (ASP-DAC 2017)
    • Int'l Joint Research
  • [Presentation] Design of an Energy-Autonomous Bio-Sensing System Using a Biofuel Cell and 0.19V 53uW Integrated Supply-Sensing Sensor with a Supply-Insensitive Temperature Sensor and Inductive-Coupling Transmitter2017

    • Author(s)
      Atsuki Kobayashi, Kei Ikeda, Yudai Ogawa, Matsuhiko Nishizawa, Kazuo Nakazato, and Kiichi Niitsu
    • Organizer
      ACM/IEEE Asia and South Pacific Design Automation Conference (ASP-DAC 2017)
    • Int'l Joint Research
  • [Presentation] Design of an energy-autonomous supply-sensing biosensor platform using biofuel cells and human-body-communication transmitter2017

    • Author(s)
      Keisuke Kayano, Keisuke Itakura, Atsuki Kobayashi, Yuya Nishio, Kazuo Nakazato and Kiichi Niitsu
    • Organizer
      9th International Symposium on Advanced Plasma Science and its Applications for Nitrides and Nano materials (ISPlasma2017)
    • Int'l Joint Research
  • [Presentation] A CMOS Electrochemical Impedance Spectroscopy Biosensor in 55nm DDC Technology for High-Sensitivity Cell-State Monitoring2017

    • Author(s)
      Keisuke Itakura, Keisuke Kayano, Kazuo Nakazato and Kiichi Niitsu
    • Organizer
      9th International Symposium on Advanced Plasma Science and its Applications for Nitrides and Nano materials (ISPlasma2017)
    • Int'l Joint Research
  • [Presentation] A CMOS-based bacteria-counting sensor with 1024 × 1024 baceteria-sized microelectrode array and current integration circuit2017

    • Author(s)
      Kohei Gamo, Kazuo Nakazato and Kiichi Niitsu
    • Organizer
      9th International Symposium on Advanced Plasma Science and its Applications for Nitrides and Nano materials (ISPlasma2017)
    • Int'l Joint Research
  • [Presentation] NASBA Amplification and Detection of Micro-RNA Using Plasma-Treated CMOS FET-Based Redox Potential Sensor Array2017

    • Author(s)
      Masaki Kawase, Kazuo Nakazato and Kiichi Niitsu
    • Organizer
      9th International Symposium on Advanced Plasma Science and its Applications for Nitrides and Nano materials (ISPlasma2017)
    • Int'l Joint Research
  • [Presentation] Design and Physical Implementation of Pad-Less CMOS Biosensor Array Chip for Low-Cost Packaging-Less Bio-Imaging Platform2017

    • Author(s)
      Yuuya Hayashi, Kazuo Nakazato and Kiichi Niitsu
    • Organizer
      9th International Symposium on Advanced Plasma Science and its Applications for Nitrides and Nano materials (ISPlasma2017)
    • Int'l Joint Research
  • [Presentation] 電力自立ヘルスケアIoTに向けたバイオ発電素子と低消費電力CMOS集積回路を用いた発電センシング一体型集積センサ2017

    • Author(s)
      新津 葵一
    • Organizer
      電子情報通信学会総合大会
    • Invited
  • [Presentation] Live Demonstration: Current-Mode Analog-to-Time Converter for a Large Scale CMOS Biosensor Array2016

    • Author(s)
      Kei Ikeda, Atsuki Kobayashi, Kazuo Nakazato, and Kiichi Niitsu
    • Organizer
      IEEE Biomedical Circuits and Systems Conference (BioCAS 2016)
    • Int'l Joint Research
  • [Presentation] Live Demonstration: Noise-Immune Current-Integration-Based CMOS Amperometric Sensor Platform with 1.2 um × 2.05 um Electroless-Plated Microelectrode Array for Robust Bacteria Counting2016

    • Author(s)
      Kohei Gamo, Kazuo Nakazato, and Kiichi Niitsu
    • Organizer
      IEEE Biomedical Circuits and Systems Conference (BioCAS 2016)
    • Int'l Joint Research
  • [Presentation] An Energy-Autonomous Bio-Sensing System Using a Biofuel Cell and 0.19V 53μW 65nm-CMOS Integrated Supply-Sensing Sensor with a Supply-Insensitive Temperature Sensor and Inductive-Coupling Transmitter2016

    • Author(s)
      Atsuki Kobayashi, Kei Ikeda, Yudai Ogawa, Matsuhiko Nishizawa, Kazuo Nakazato, and Kiichi Niitsu
    • Organizer
      IEEE Biomedical Circuits and Systems Conference (BioCAS 2016)
    • Int'l Joint Research
  • [Presentation] A Current-Mode Analog-to-Time Converter with Short-Pulse Output Capability Using Local Intra-Cell Activation for High-Speed Time Domain Biosensor Array2016

    • Author(s)
      Kei Ikeda, Atsuki Kobayashi, Kazuo Nakazato, and Kiichi Niitsu
    • Organizer
      IEEE Nordic Circuits and Systems Conference (NORCAS 2016)
    • Int'l Joint Research
  • [Presentation] ―あなたと考えるあたらしい科学とくらし―『コンピュータが人間を健康にする未来を目指そう!』2016

    • Author(s)
      新津 葵一
    • Organizer
      サイエンティストクエスト
    • Invited
  • [Remarks] 研究代表者の研究グループ紹介ページ

    • URL

      http://www.nuee.nagoya-u.ac.jp/labs/nakazatolab/

  • [Remarks] 研究代表者の研究成果紹介ページ

    • URL

      https://www.niitsulab.info/

  • [Remarks] サイエンティスト・クエスト「コンピュータが人間を健康にする未来を目指そう!」

    • URL

      http://www.miraikan.jst.go.jp/event/1605301120013.html

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Published: 2018-12-17  

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