Studies on Chemical Synthesis of Polyketide-Derived, Biologically Active Complex Natural Products

2020 Fiscal Year Final Research Report

• Project/Area Number: 16H06351
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Organic chemistry
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: Suzuki Keisuke 東京工業大学, 科学技術創成研究院, 特命教授 (90162940)
• Co-Investigator(Kenkyū-buntansha): 大森 建 東京工業大学, 理学院, 准教授 (50282819) ; 安藤 吉勇 東京工業大学, 理学院, 助教 (40532742) ; 瀧川 紘 京都大学, 薬学研究科, 講師 (70550755)
• Project Period (FY): 2016-05-31 – 2021-03-31
• Keywords: ポリケチド / 二量化 / 天然有機化合物 / 全合成 / オリゴマー化 / ハイブリッド化

Outline of Final Research Achievements

The project on “Studies on Chemical Synthesis of Polyketide-Derived, Biologically Active Complex Natural Products” has been performed at the total synthesis of various complex natural products derived from type-II polyketide biosynthesis. Particular focus was laid on the natural process of evolving the structure diversity and complexity, trying to gain inspiration in developing new synthetic strategies and tactics in organic synthesis. More specifically, we focused three biosynthetic processes by which molecular complexity is enhanced, 1) oxidative structure modification, 2) oligomerization, and 3) hybridization, and aimed at the realization of these complexity/diversity-generating processes in chemical synthesis. Throughout the five-year research, we have succeeded in developing several synthetic routes to some useful/interesting classes of bioactive molecules.

Free Research Field

有機合成化学

Academic Significance and Societal Importance of the Research Achievements

本研究によって見出されたポリケチド系天然有機化合物の合成経路ならびに合成方法論は、独自性が高く、今後、様々な関連化合物を合成する際の選択肢の一つとなりうるものである。また、いくつかの標的化合物の合成研究を通じ、個々の化合物の持つ独特の性質に由来する合成の困難さや興味深い知見が得られている。