2017 Fiscal Year Final Research Report
Elucidate that fatigue-induced viral factors affect the onset of depression
Project/Area Number |
16H07220
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Psychiatric science
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Research Institution | Jikei University School of Medicine |
Principal Investigator |
Oka Naomi 東京慈恵会医科大学, 医学部, 助教 (00704503)
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Project Period (FY) |
2016-08-26 – 2018-03-31
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Keywords | うつ病 / ウイルス / ストレス / 精神疾患 / 抗うつ薬 |
Outline of Final Research Achievements |
Small protein encoded by the intermediate stage transcript of HHV-6 (SITH-1) is a latent infected protein expressed by the human herpes virus (HHV-) 6 reactivated in a fatigue or stress-dependent manner. In order to elucidate the mechanism by which SITH-1 is involved in the development of depression, we created a SITH-1 expressing mouse model (SITH-1 mouse). SITH-1 mice showed depression-like behavior and stress vulnerability. Further studies showed that SITH-1 expression increased intracellular calcium concentration and subsequently induced apoptosis in the olfactory bulb, resulting in inhibition of hippocampal neurogenesis. Therefore, it is considered that SITH-1 mouse had a property of impaired stress response.
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Free Research Field |
ウイルス学
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