Molecular function of DR6 for controlling peripheral immunological cells

2019 Fiscal Year Final Research Report

• Project/Area Number: 16K08570
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Kitasato University (2019); Asahikawa Medical College (2016-2018)
• Principal Investigator: Fujikura Daisuke 北里大学, 獣医学部, 特任准教授 (70547794)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: DR6 / SLE / T細胞

Outline of Final Research Achievements

Activation of peripheral T cells is tightly restricted to prevent induction of auto immunological diseases, such as systemic lupus erythematosus (SLE). Here we report molecular details of an orphan immune regulator, death receptor 6 (DR6/TNFRSF21) in lupus-like disease progression in mice.

Free Research Field

分子免疫学

Academic Significance and Societal Importance of the Research Achievements

本研究成果により、自己免疫性炎症性疾患の一つである全身性エリテマトーデスのモデルマウス病態発症制御において、DR6分子を介したメカニズムの存在が示唆された。本知見から、DR6分子が上記疾患の治療標的の一つとなりうる可能性が示唆された。