2019 Fiscal Year Final Research Report
Molecular function of DR6 for controlling peripheral immunological cells
Project/Area Number |
16K08570
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General medical chemistry
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Research Institution | Kitasato University (2019) Asahikawa Medical College (2016-2018) |
Principal Investigator |
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Project Period (FY) |
2016-04-01 – 2020-03-31
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Keywords | DR6 / SLE / T細胞 |
Outline of Final Research Achievements |
Activation of peripheral T cells is tightly restricted to prevent induction of auto immunological diseases, such as systemic lupus erythematosus (SLE). Here we report molecular details of an orphan immune regulator, death receptor 6 (DR6/TNFRSF21) in lupus-like disease progression in mice.
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Free Research Field |
分子免疫学
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Academic Significance and Societal Importance of the Research Achievements |
本研究成果により、自己免疫性炎症性疾患の一つである全身性エリテマトーデスのモデルマウス病態発症制御において、DR6分子を介したメカニズムの存在が示唆された。本知見から、DR6分子が上記疾患の治療標的の一つとなりうる可能性が示唆された。
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