2018 Fiscal Year Final Research Report
Analysis of cancer associated microenvironment in colorectal liver metastasis and application of histopathological asessment
Project/Area Number |
16K08655
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
|
Research Institution | Iwate Medical University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
菅井 有 岩手医科大学, 医学部, 教授 (20187628)
|
Project Period (FY) |
2016-04-01 – 2019-03-31
|
Keywords | 大腸癌肝転移 / 術前化学療法 / 病理診断 / 癌関連線維芽細胞 / 画像診断 |
Outline of Final Research Achievements |
(1) We showed histological findings for every representative chemotherapy regimen including molecular target drug for colorectal liver metastases (CRLM) to clarify the effects of preoperative chemotherapy. (2) The immunohistological expression status of cancer-associated fibroblasts was lower in metastases of lymph node and liver than in primary colorectal lesions. In addition, there was no difference in immunohistological expression status between CRLM with chemotherapy group and without chemotherapy group. (3) Morphologic appearance of CRLM after preoperative chemotherapy on contrast-enhanced CT scans was correlated with detailed histologic findings and the histologic tumor response regarding necrosis.
|
Free Research Field |
病理診断
|
Academic Significance and Societal Importance of the Research Achievements |
大腸癌肝転移の治療の主体は手術療法であり,切除された肝転移巣に対する病理学的評価は予後を予測する因子となることが報告されている.近年では肝転移巣の切除前に化学療法を行う機会が増加しており,今回の研究により,術前化学療法(分子標的治療薬を含む)を行った際の組織学的評価方法が確立された.さらに,大腸癌の原発巣と転移巣の違い,術前化学療法の有無による癌関連線維芽細胞の発現状態が明らかになった.加えて,詳細な組織学的所見に基づいて画像診断に反映されている所見を明らかにしたことで,更なる画像診断の精度向上,予後の推測に寄与するものと考えられた.
|