2018 Fiscal Year Final Research Report
Identification of anti-HIV immunity information from Asia, and its application to international HIV vaccine development.
| Project/Area Number |
16K08843
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Nagasaki University |
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Principal Investigator |
MORI Masahiko 長崎大学, 熱帯医学研究所, 客員研究員 (50643988)
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| Research Collaborator |
ARIYOSHI Koya
YASUNAMI Michio
GOULDER Philip
SRIWANTHANA Busarawan
JOOSTE Pieter
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | HIV / KIR / HLA / 南アフリカ / タイ |
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| Outline of Final Research Achievements |
We identified the difference of immune cells effecting on HIV clinical outcomes between South African and Thai HIV patients. (1)Among South African population, patients with HLA-C*16:01+KIR2DL3+ had worse clinical outcome, and (2)among Thai population, patients with HLA-B*46:01+KIR2DL2+ had worse clinical outcome, and ones with HLA-C*12:03+KIR2DL2+ had better outcome.
These suggested the possibility of regional difference in efficacy of newly-developed medicine effecting through HLA-KIR pathways. These information would support the discovery and development of novel HIV medicines and treatment.
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| Free Research Field |
免疫学
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| Academic Significance and Societal Importance of the Research Achievements |
学術的意義：(1)これまで知られていた細胞傷害性T細胞を介した免疫系統だけでなく、ナチュラルキラー細胞を介した免疫系統でもHIV感染後臨床経過への影響を示唆する（2）ただし細胞傷害性T細胞におけるHLA-B*57のように、人種間・ウィルス型を越えウィルスを抑制するような共通したHLA-KIRの組み合わせは検出されなかった。
社会的意義：免疫系統を利用した薬剤開発においては、人種・地域毎でその効果に差が出る可能性があることを示唆した。
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