Investigation of medical significance of pentosidine (advanced glycation end products) by comparing the general population and stroke patients in Japan

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K09091
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: WATANABE MAKOTO 国立研究開発法人国立循環器病研究センター, 病院, 医長 (40343446)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: pentosidine / general population / stroke patients / epidemiology / atherosclerosis

Outline of Final Research Achievements

In the general population, serum pentosidine levels didn't clearly differ between sex, but they drastically increased with increase in age. The proportion of treatment(hypertension, dyslipidemia and diabetes) and intima media thickness in the carotid ultrasonography increased with elevation in pentosidine levels.
In comparing serum pentosidine levels between stroke patients and the general population (age and sex matching), pentosidine levels were lower in stroke patients. On the other hand, the proportion of treatment(hypertension, dyslipidemia and diabetes) and the prevalences of cigarette smoking and atrial fibrillation were higher in stroke patients. We couldn't elucidate the reason why serum pentosidine levels were lower in stroke patiens with higher prevalences of atherosclerotic risk factors.

Free Research Field

epidemiology

Academic Significance and Societal Importance of the Research Achievements

大規模な都市部の地域一般住民集団（約１０００人）を対象として、血中ペントシジンの基本特性を明らかにしており、ペントシジンをはじめとした終末糖化産物に関する今後の研究の基礎資料として公衆衛生学的な意義は大きい。また、動脈硬化の代表的な指標の一つである頸動脈超音波検査での最大内膜中膜複合体厚と血中ペントシジンとの正の関連も示されており、一般集団での動脈硬化のマーカーの一つとしての可能性が示された。