Novel Therapeutics for Vascular Calcification

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K09655
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Keio University
• Principal Investigator: Tadashi Yoshida 慶應義塾大学, 医学部(信濃町), 准教授 (00306713)
• Research Collaborator: HAYASHI Matsuhiko ; YAMASHITA Maho ; HORIMAI Chihiro
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 血管石灰化 / 慢性腎臓病

Outline of Final Research Achievements

Vascular calcification is highly prevalent in patients with chronic kidney disease. The aim of the present study was to determine the role of pro-inflammatory nuclear factor-kB signaling for vascular calcification in chronic kidney disease. We found that the nuclear factor-kB signaling in vascular smooth muscle cells plays an important role in phosphate-induced vascular calcificaton in chronic kidney disease.

Free Research Field

血管生物学

Academic Significance and Societal Importance of the Research Achievements

慢性腎臓病における血管石灰化は、心血管イベントを引き起こす原因となる。しかし、現在のところ血管石灰化の有効な治療薬は存在しない。今回の研究では、慢性腎臓病においては、血管平滑筋におけるNF-kB活性が血管石灰化に重要な役割を果たしていることを明らかにした。血管平滑筋においてNF-kBを制御することが、新たな治療法となる可能性を示した。