Dynamic neuropathological study on CBD and PSP.

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K09734
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Saito Yuko 国立研究開発法人国立精神・神経医療研究センター, 病院 臨床検査部, 医長 (60344066)
• Research Collaborator: MURAYAMA shigeo
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 臨床神経形態学 / THK 5351 / 病理診断 / 画像病理連関

Outline of Final Research Achievements

In this study, pathological retrospective examination and imaging and autopsy pathology linkage of tau PET (THK 5351) imaging cases were performed. In retrospect, both PSP and CBD considered that the basal ganglia was appropriate as the region of interest. In this example of PET imaging, it was possible to examine linkage in 2 cases in which the clinical case was frontotemporal dementia and the autopsy diagnosis was CBD, and both the clinical and pathological diagnosis were PSP. The site with strong accumulation of this PET was strong in both tau deposition and degeneration. During the study period, it became clear that this tau PET binds to MAO-B, but there is also a disease that is specific in the site of degeneration, and from that point of view it is considered that there is an active pathway of this PET.

Free Research Field

医歯薬学

Academic Significance and Societal Importance of the Research Achievements

大脳皮質基底核変性症（CBD）と進行性核上性麻痺（PSP）は神経病理学的には厳密に鑑別診断は可能だが、臨床的には不能である。現在進行中のCBD/ PSPバイオマーカー蓄積事業は神経病理診断の裏打ちを持たない。
我々の事前検討で、神経病理学的にタウ沈着が両疾患で最も差があるのは、大脳白質と基底核である。本研究は、我々が構築している生前同意ブレインバンク献脳登録者中CBD/ PSPの臨床診断を受けている症例にタウイメージPETを行い大脳白質・基底核の取込みを測定し、死亡時神経病理学的にタウ沈着との関連を得ることで、生前鑑別診断法を確立し、今後の早期診断、早期治療の道につなげる。