2018 Fiscal Year Final Research Report
Experimental evaluation of postmortem enhanced CT image and histopathology
| Project/Area Number |
16K10290
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
Hyodoh Hideki 北海道大学, 医学研究院, 准教授 (30306154)
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| Co-Investigator(Kenkyū-buntansha) |
的場 光太郎 北海道大学, 医学研究院, 講師 (00466450)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | 死後造影CT / 動物実験 / 死後画像 / 法医放射線 / 放射線診断 |
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| Outline of Final Research Achievements |
We evaluate the influence of infusion on cadaver lung, and to evaluate the mechanism of increasing lung density in postmortem CT. Comparing among the antemortem, and 80 ml injection and 160 ml injection groups, the lung density was relatively increasing after saline injection. The 160 ml injection group presented statistically increased lung density compared with antemortem and the 80 ml injection group. From segmented volume data analysis, the highly edematous lung area was statistically increasing; in contrast, the lung volume was not changed after saline injection. Therefore, depending on the infusion volume, the lung density increases, the aerated lung volume decreases, and the edematous lung volume increases in postmortem CT.
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| Free Research Field |
医歯薬学
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| Academic Significance and Societal Importance of the Research Achievements |
死後造影では、引き続き解剖が実施される場合に肺重量が影響を受けるため、死因判定に一定程度の影響が生じることが明らかとなった。動物実験を通じて、肺重量が増加する現象、肺重量を増加させない輸液投与量を明らかにした。
上記投与量を上限とした造影法によって、解剖前でも肺重量増加を生じさせない造影法を確立することができ、高い正診率で死後造影CTを実施可能となった。
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