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2019 Fiscal Year Final Research Report

Elucidation of male infertility by epigenome analysis of iPS cells derived from male infertility and stem cell research

Research Project

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Project/Area Number 16K11072
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionToho University

Principal Investigator

KOBAYASHI Hideyuki  東邦大学, 医学部, 准教授 (10408875)

Project Period (FY) 2016-04-01 – 2020-03-31
Keywords男性不妊症 / iPS細胞 / マイクロミニピッグ
Outline of Final Research Achievements

We could not perform satisfied research because of we were damaged our freezer of -80℃. We lost all tissues, cells, and reagents due to this accident. However, we found that the induction of iPS cells derived from micro-minipigs are very difficult more than iPS cells of mouse and human. In future, we think that it is necessary to perform the induction of iPS cells derived from micro-minipigs. In present, we collect new testis tissues derived from patients with male infertility. We consider the restart of our research in future.

Free Research Field

男性不妊症

Academic Significance and Societal Importance of the Research Achievements

研究に用いる大半の組織をアクシデントにより失ったため、満足する研究は施行できなかった。しかし、マイクロミニピッグでのiPS細胞は、マウスやヒトに比べて難易度が高いことが分かった。マイクロミニピッグの研究は、ヒト生殖細胞の代替え研究としては重要な位置を占めていると考えている。今後は、マイクロミニピッグのiPS細胞の誘導をテーマとした研究も必須と思われる。また、現在、新たに男性不妊症患者における精巣組織を採取しており、集まったところで、研究の再開を予定したいと考えている。

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Published: 2021-02-19  

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