The effect of low level laser therapy on endometrial function and management of inplantation failure

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K11094
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Oita University
• Principal Investigator: KAWANO YASUSHI 大分大学, 医学部, 准教授 (40274758)
• Co-Investigator(Kenkyū-buntansha): 奈須 家栄 大分大学, 医学部, 教授 (30274757) ; 楢原 久司 大分大学, 医学部, 教授 (60211447)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 着床 / 不妊症

Outline of Final Research Achievements

To investigate the effect of low level laser therapy (LLLT) on endometrial function, the kinase activation via protease-activated receptor (PAR)-1 in endometrial stromal cells (ESCs) and decisual cells (DSCs) were investigated.
Following stimulation by PAR-1 tetherd ligand, the activation of extracellular signal-regulated kinase (ERK), production of chemokines and increasing of cellular motility were detected. LLLT also activated the ERK. Our findings demonstrate a new role for PAR-1 in in vitro decidualization with increased chemokine eproduction and cell migration. LLLT may also contribute to improve the implantation failure with activation of intracellular singal transduction.

Free Research Field

生殖医学

Academic Significance and Societal Importance of the Research Achievements

着床不全症例に対して、脱落膜化による細胞内情報伝達系の活性化が妊娠成立に重要であることが確認できたが、低反応レベルレーザーも同様の細胞内情報伝達系の活性化を引き起こすため、着床不全の治療に応用できる可能性が示唆される。