Study on autophagy and tumor immunology by Interleukin 18 in CD8-positive T cells

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K11220
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Hyogo Medical University
• Principal Investigator: Tsuzuki Kenzo 兵庫医科大学, 医学部, 准教授 (50441308)
• Research Collaborator: Hashimoto Kengo ; Okazaki Ken ; Oka Naoto ; Nishikawa Hiroki
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 免疫学

Outline of Final Research Achievements

Although there have been several reports that simultaneously stimulated natural killer cells (NK cells) with IL-12, 15, and 18, the cytotoxicity of NK cells by individual cytokine stimulation was unknown. This study demonstrated in more detail that NK cells show increased cytotoxic activity by IL-15 and 18 stimulation and decreased by IL-12. In the clinical research on inflammatory diseases, we proposed scoring systems that can predict the postoperative course from the pre- and intra-operative findings of chronic rhinosinusitis, and the usefulness were discussed.

Free Research Field

耳鼻咽喉科・頭頸部外科

Academic Significance and Societal Importance of the Research Achievements

悪性腫瘍に対する免疫治療において、natural killer細胞（NK細胞）は重要な役割をもつことが報告されている。サイトカインによる刺激を受けたNK細胞のphenotypeの詳細な機能や分化条件について解明した。炎症疾患における研究では、慢性副鼻腔炎の術前、術中所見から、術後経過を推測しうる因子を解明できた。