2018 Fiscal Year Final Research Report
Development of novel treatment targeting cancer stromal cells in standard treatment-resistant oral squamous cell carcinoma
Project/Area Number |
16K11521
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pathobiological dentistry/Dental radiology
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Research Institution | Keio University |
Principal Investigator |
Asoda Seiji 慶應義塾大学, 医学部(信濃町), 講師 (80296706)
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Co-Investigator(Kenkyū-buntansha) |
森川 暁 慶應義塾大学, 医学部(信濃町), 講師 (00424169)
吉川 桃子 慶應義塾大学, 医学部(信濃町), 訪問研究員 (50570967)
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Keywords | CD44v / 口腔扁平上皮癌 / SpCC |
Outline of Final Research Achievements |
Our group focused on cancer-associated mesenchymal / stromal cells of cetuximab-resistant oral squamous cell carcinoma. We aimed at personalized treatment by constructing expression profiles of CD44v and novel mesenchymal markers.Analysis of cetuximab-resistant undifferentiated oral squamous cell carcinoma using tissue sample revealed that tissue-derived cells expressed both epithelial marker, EpCAM and mesenchymal marker, PDGFRα.The cancer stem cell marker CD44v-positive cells were identified in both cell fractions.
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Free Research Field |
口腔がん
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Academic Significance and Societal Importance of the Research Achievements |
SpCCの検体を用いて間質特異的細胞表面マーカーやその細胞特性評価を行い、病理診断のみでは予測できない細胞の性質や機能を明らかにした。その上で、効果的薬剤が定まっていないSpCCに対するイマチニブによる新規治療の可能性を見出した。
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