Elucidation of the novel mechanism to retard the aging by stem cells from human exfoliated deciduous teeth

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K11806
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Kyushu University
• Principal Investigator: Yamaza Haruyoshi 九州大学, 歯学研究院, 准教授 (30336151)
• Co-Investigator(Kenkyū-buntansha): 山座 孝義 九州大学, 歯学研究院, 准教授 (80304814)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 乳歯歯髄由来間葉系幹細胞 / カロリー制限

Outline of Final Research Achievements

The objective of this study is to elucidate the novel mechanism to retard the aging by stem cells from human exfoliated deciduous teeth (SHED). The idea to compare SHED-injective mice and the mice under caloric restriction, which extends the average and maximum lifespan, is the breakthrough foundation of this study to the novel mechanism for the aging. The outputs of this study could give the impression at home and abroad, and be basis of the drug delivery to retard the aging.

Free Research Field

小児歯科学

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は国内外に大きなインパクトを与えるとともに、アンチエイジング医薬品開発の基盤となりうることが十分に期待される。