High blood-level adiponectin induces muscle atrophy in fast-type muscle?

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K13022
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Sports science
• Research Institution: Toyohashi Sozo University
• Principal Investigator: GOTO Katsumasa (山下勝正) 豊橋創造大学, 保健医療学部, 教授 (70239961)
• Co-Investigator(Renkei-kenkyūsha): OHNO Yoshitaka 豊橋創造大学, 保健医療学部, 講師 (80440808) ; YOKOYAMA Shingo 豊橋創造大学, 保健医療学部, 助教 (30706859) ; EGAWA Tatsuro 豊橋創造大学, 大学院健康科学研究科, 協力研究員 (00722331) ; NAGATOMI Ryoichi 東北大学, 大学院医工学研究科, 教授 (20208028)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 骨格筋 / adiponectin / C2C12 / 筋萎縮 / 加齢 / 速筋

Outline of Final Research Achievements

the purpose of this study was to investigate the effects of high-level adiponectin on skeletal muscle mass. High concentration of adiponectin receptor agonist AdipoRon suppressed myogenic differentiation of C2C12 cells in a dose-dependent manner. Repetitive administration of AdipoRon caused to decrease in muscle wet weight of fast-type plantaris, but not of slo-type soleus, in mice. Evidences from this study suggest that high blood-level adiponectin may be a cause of aging-associated skeletal muscle atrophy, so-called sarcopenia,that exhibits fast muscle-specific skeletal muscle atrophy.

Free Research Field

骨格筋可塑性機構