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2017 Fiscal Year Final Research Report

Effects of insulin and exercise on brain glucose uptake

Research Project

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Project/Area Number 16K13024
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Sports science
Research InstitutionFukuoka University

Principal Investigator

Kawanaka Kentaro  福岡大学, スポーツ科学部, 教授 (80339960)

Co-Investigator(Kenkyū-buntansha) 檜垣 靖樹  福岡大学, スポーツ科学部, 教授 (10228702)
増田 紘之  新潟医療福祉大学, 健康科学部, 助手 (10738561)
羅 成圭  福岡大学, スポーツ科学部, 助教 (60741999)
Project Period (FY) 2016-04-01 – 2018-03-31
Keywordsインスリン / 運動 / 脳 / 糖取り込み / ワートマニン / デキサメタゾン
Outline of Final Research Achievements

Brain glucose uptake plays an important role in brain function (e.g. cognitive function). To explore the mechanisms of brain glucose uptake, we examined the effects of insulin and exercise on brain glucose uptake. Administration of insulin into blood or lateral ventricle had no effect on brain glucose uptake. On the other hand, 30min of moderate intensity exercise increased glucose uptake in each brain tissues (cerebellum, brainstem, hippocampus, hypothalamus), while 120min exercise did not increase them. Thus, it is unlikely that insulin increases brain glucose uptake. In addition, exercise increases brain glucose uptake, while exercise-induced increase is suppressed when exercise is prolonged.

Free Research Field

運動生理学

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Published: 2019-03-29  

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