Elucidation of the action domain of polyunsaturated fatty acids to develop new drug for hypertriglyceridemia

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K13040
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: University of Tsukuba
• Principal Investigator: Yahagi Naoya 筑波大学, 医学医療系, 准教授 (60420246)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 多価不飽和脂肪酸 / 栄養 / 転写

Outline of Final Research Achievements

The transcription factor SREBP-1 is a transcriptional regulatory factor that regulates the expression levels of various enzymes involved in triglyceride synthesis in the liver. Polyunsaturated fatty acids (PUFAs) have long been known to suppress triglyceride synthesis in the liver, and we have found that this action of PUFAs is mediated through inhibition of SREBP-1. In this study, in order to screen compounds libraries to get novel compounds that specifically act on the same mechanism as PUFAs and have a stronger SREBP-1 inhibitory effect than PUFA, stable cell line necessary for high-throughput screening was established as an assay system to be used.

Free Research Field

代謝学、栄養学、分子生物学