Elucidation of the mechanism of cancer-resistance in the naked mole rat.

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K14602
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: Hokkaido University
• Principal Investigator: Miura Kyoko 北海道大学, 遺伝子病制御研究所, 准教授 (80583062)
• Co-Investigator(Kenkyū-buntansha): 坊農 秀雅 大学共同利用機関法人情報・システム研究機構(機構本部施設等), 大学共同利用機関等の部局等, 准教授 (20364789)
• Co-Investigator(Renkei-kenkyūsha): SHIMIZU Atsushi 岩手医科大学, いわて東北メディカル・メガバンク機構, 教授 (30327655)
• Research Collaborator: OIWA Yuki 北海道大学, 遺伝子病制御研究所, 大学院生
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: ハダカデバネズミ

Outline of Final Research Achievements

The naked mole rat (NMR) is the longest-living rodent in the world and has extraordinary cancer-resistance. We studied the mechanisms of NMR-specific tumor-suppressive phenomenon, ASIS (ARF suppression-induced senescence). We performed mRNA-seq analyses and found the genes which are upregulated or downregulated upon ASIS induction. We also found NMR-specific regulation of signal transduction in ASIS.

Free Research Field

幹細胞学、老化生物学、ハダカデバネズミ