Comprehensive study on individual genetic variability in dietary effects using genome-wide association studies

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K14920
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Food science
• Research Institution: The University of Tokyo
• Principal Investigator: Kato Hisanori 東京大学, 総括プロジェクト機構, 特任教授 (40211164)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: ゲノム / 遺伝子多型 / ゲノムワイド関連解析 / コーヒー / 魚食 / アレルギー / 食習慣

Outline of Final Research Achievements

For the prevention of diseases through personalized nutrition, it is necessary to elucidate the genetic background of individual variability in the effects of foods. Nevertheless, large-scale studies conducted in the Japanese population are limited.
To reveal the association between SNPs and food factors, we performed genome-wide association studies (GWAS) on dietary habits using the large-scale SNP database of the Japanese population and an internet-based questionnaire survey. We identified SNPs significantly associated with four selected dietary habits, demonstrating the effectiveness of the internet-based genomic cohort studies. We provide the first evidence that fish intake frequency had a significant interaction with genotypes. Also, we found that in Japanese population the SNP different from European population affects dietary habits.

Free Research Field

食品科学