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2017 Fiscal Year Final Research Report

Induction of diabetes by CRTC1 deficiency

Research Project

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Project/Area Number 16K14925
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Food science
Research InstitutionKyoto University

Principal Investigator

Matsumura Shigenobu  京都大学, 農学研究科, 助教 (70467413)

Research Collaborator Montminy Marc  Salk Institute, Professor
Project Period (FY) 2016-04-01 – 2018-03-31
Keywords糖尿病 / 高脂肪食 / 転写因子
Outline of Final Research Achievements

We studied the induction mechanism of diabetes in CRTC1 knockout mouse. We found that High fat diet (HFD) induced severe hyperglycemia, hyperinsulinemia and insulin resistance in CRTC1KO mice. Furthermore, HFD elicited fatty liver, lipodystrophy and inflammation in visceral adipose tissue in CRTC1 KO mice. Tranplantation of adipose tissue from Wild type animal into CRTC1 KO mice successfully cured diabetes. These results indicate that HFD may activate CRTC1 in adipose tissue, suppressing inflammation. Also, CRTC1 may regulate gene expression related to glucose homeostasis.

Free Research Field

栄養化学

URL: 

Published: 2019-03-29  

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